Results 81 to 90 of about 1,747,943 (295)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Final report on the STELLAR Delphi study: Future directions for TEL and TEL research: areas of tension, core research areas and grand challenge problems

, 2012
In this report on the STELLAR Delphi study, we present the results of the final global survey, that is the 4th STELLAR Delphi round, and illustrate the elaboration and dissemination of these results (5th STELLAR Delphi round).
Spada, Hans, Plesch, Christine, Wiedmann, Michael   +2 more
core   +2 more sources

The Hubble Constant Anchor Galaxy NGC 4258: Metallicity and Distance from Blue Supergiants

The Astrophysical Journal
A quantitative spectroscopic study of blue supergiant stars in the Hubble constant anchor galaxy NGC 4258 is presented. The non-LTE analysis of Keck I telescope LRIS spectra yields a central logarithmic metallicity (in units of the solar value) of [ Z ] =
Rolf-Peter Kudritzki, Miguel A. Urbaneja, Fabio Bresolin, Lucas M. Macri, Wenlong Yuan, Siyang Li, Gagandeep S. Anand, Adam G. Riess   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Intermediate report on the Delphi study: Findings from the 2nd and the 3rd STELLAR Delphi rounds: Areas of tension and core research areas

, 2011
This intermediate report on the STELLAR Delphi study closes the gap between the first deliverable on the Delphi study D1.3 (Spada et al. 2010) which was published in July 2010 and the second and final deliverable D1.6 which is planned for January 2012 ...
Spada, Hans, Plesch, Christine, Kaendler, Celia   +2 more
core   +2 more sources

Mapping the Distant and Metal-poor Milky Way with SDSS-V

The Astrophysical Journal
The fifth-generation Sloan Digital Sky Survey (SDSS-V) is conducting the first all-sky low-resolution spectroscopic survey of the Milky Way’s (MW) stellar halo.
Vedant Chandra, Phillip A. Cargile, Alexander P. Ji, Charlie Conroy, Hans-Walter Rix, Emily Cunningham, Bruno Dias, Chervin Laporte, William Cerny, Guilherme Limberg, Avrajit Bandyopadhyay, Ana Bonaca, Andrew R. Casey, John Donor, José G. Fernández-Trincado, Peter M. Frinchaboy, Pramod Gupta, Keith Hawkins, Jennifer A. Johnson, Juna A. Kollmeier, Madeline Lucey, Ilija Medan, Szabolcs Mészáros, Sean Morrison, José Sánchez-Gallego, Andrew K. Saydjari, Conor Sayres, Kevin C. Schlaufman, Keivan G. Stassun, Jamie Tayar, Zachary Way   +30 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Hedgehog: An Isolated Quiescent Dwarf Galaxy at 2.4 Mpc

The Astrophysical Journal Letters
It is well known that almost all isolated dwarf galaxies are actively forming stars. We report the discovery of dw1322m2053 (nicknamed Hedgehog), an isolated quiescent dwarf galaxy at a distance of 2.40 ± 0.15 Mpc with a stellar mass of M _⋆ ≈ 10 ^5.8 M ...
Jiaxuan Li, Jenny E. Greene, Scott G. Carlsten, Shany Danieli   +3 more
doaj   +1 more source

Distance to Sh2–106 from Gaia DR3 and its embedded radio population: Implications for a candidate explosive outflow

Astronomy & Astrophysics
Sh2–106 has recently been proposed as a candidate explosive molecular outflow, but the physical interpretation of the region depends critically on its distance.
Dzib Sergio A.
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source