Results 81 to 90 of about 12,062 (300)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The Hubble Constant Anchor Galaxy NGC 4258: Metallicity and Distance from Blue Supergiants

The Astrophysical Journal
A quantitative spectroscopic study of blue supergiant stars in the Hubble constant anchor galaxy NGC 4258 is presented. The non-LTE analysis of Keck I telescope LRIS spectra yields a central logarithmic metallicity (in units of the solar value) of [ Z ] =
Rolf-Peter Kudritzki, Miguel A. Urbaneja, Fabio Bresolin, Lucas M. Macri, Wenlong Yuan, Siyang Li, Gagandeep S. Anand, Adam G. Riess   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hedgehog: An Isolated Quiescent Dwarf Galaxy at 2.4 Mpc

The Astrophysical Journal Letters
It is well known that almost all isolated dwarf galaxies are actively forming stars. We report the discovery of dw1322m2053 (nicknamed Hedgehog), an isolated quiescent dwarf galaxy at a distance of 2.40 ± 0.15 Mpc with a stellar mass of M _⋆ ≈ 10 ^5.8 M ...
Jiaxuan Li, Jenny E. Greene, Scott G. Carlsten, Shany Danieli   +3 more
doaj   +1 more source

Pulsating stars as distance indicators and stellar population tracers [PDF]

, 2016
Pulsating stars can play a fundamental role as distance indicators to set the astronomical distance scale and to trace different stellar populations to infer information on the star formation history of the host galaxy. The most interesting variables are
MUSELLA, ILARIA
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Mapping the Distant and Metal-poor Milky Way with SDSS-V

The Astrophysical Journal
The fifth-generation Sloan Digital Sky Survey (SDSS-V) is conducting the first all-sky low-resolution spectroscopic survey of the Milky Way’s (MW) stellar halo.
Vedant Chandra, Phillip A. Cargile, Alexander P. Ji, Charlie Conroy, Hans-Walter Rix, Emily Cunningham, Bruno Dias, Chervin Laporte, William Cerny, Guilherme Limberg, Avrajit Bandyopadhyay, Ana Bonaca, Andrew R. Casey, John Donor, José G. Fernández-Trincado, Peter M. Frinchaboy, Pramod Gupta, Keith Hawkins, Jennifer A. Johnson, Juna A. Kollmeier, Madeline Lucey, Ilija Medan, Szabolcs Mészáros, Sean Morrison, José Sánchez-Gallego, Andrew K. Saydjari, Conor Sayres, Kevin C. Schlaufman, Keivan G. Stassun, Jamie Tayar, Zachary Way   +30 more
doaj   +1 more source

High Resolution Near-Infrared Imaging Observations of the Galactic Centre [PDF]

, 2004
Ziel der vorliegenden Doktorarbeit war es, neue Erkenntnisse über die Struktur, Zusammensetzung und Dynamik des zentralen Sternhaufens unserer Milchstraße zu gewinnen.
Schödel, R., Schödel, Rainer, Schoedel, Rainer   +2 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A study of stellar population of intermediate-age globular cluster NGC 2249

Results in Physics, 2020
The Large Magellanic Cloud (LMC) star cluster NGC 2249 has been found to exhibit an extended main-sequence turn-off (eMSTO) in the color-magnitude diagram (CMD) derived from the data of the Hubble Space Telescope (HST).
Zhongmu Li, Rainer Spurzem, Caiyan Mao, Yingxin Ma, Yangyang Deng   +4 more
doaj   +1 more source