Results 51 to 60 of about 4,432 (267)

The Mass Fallback Rate of the Debris in Relativistic Stellar Tidal Disruption Events

The Astrophysical Journal, 2023
Highly energetic stellar tidal disruption events (TDEs) provide a way to study black hole characteristics and their environment. We simulate TDEs with the Phantom code in a general relativistic and Newtonian description of a supermassive black hole’s ...
T. Jankovič, A. Gomboc
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Hubble Constant Anchor Galaxy NGC 4258: Metallicity and Distance from Blue Supergiants

The Astrophysical Journal
A quantitative spectroscopic study of blue supergiant stars in the Hubble constant anchor galaxy NGC 4258 is presented. The non-LTE analysis of Keck I telescope LRIS spectra yields a central logarithmic metallicity (in units of the solar value) of [ Z ] =
Rolf-Peter Kudritzki, Miguel A. Urbaneja, Fabio Bresolin, Lucas M. Macri, Wenlong Yuan, Siyang Li, Gagandeep S. Anand, Adam G. Riess   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hedgehog: An Isolated Quiescent Dwarf Galaxy at 2.4 Mpc

The Astrophysical Journal Letters
It is well known that almost all isolated dwarf galaxies are actively forming stars. We report the discovery of dw1322m2053 (nicknamed Hedgehog), an isolated quiescent dwarf galaxy at a distance of 2.40 ± 0.15 Mpc with a stellar mass of M _⋆ ≈ 10 ^5.8 M ...
Jiaxuan Li, Jenny E. Greene, Scott G. Carlsten, Shany Danieli   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Old-Aged Stellar Population Distance Indicators

, 2018
Old-aged stellar distance indicators are present in all Galactic structures (halo, bulge, disk) and in galaxies of all Hubble types and, thus, are immensely powerful tools for understanding our Universe. Here we present a comprehensive review for three primary standard candles from Population II: (i) RR Lyrae type variables (RRL), (ii) type II Cepheid ...
Beaton, Rachael L., Bono, Giuseppe, Braga, Vittorio Francesco, Dall'Ora, Massimo, Fiorentino, Giuliana, Jang, In Sung, Martínez-Vázquez, Clara E., Matsunaga, Noriyuki, Monelli, Matteo, Neeley, Jillian R., Salaris, Maurizio   +10 more
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source