Results 61 to 70 of about 4,432 (267)

New short period stellar pulsators at large Galactocentric distances

Monthly Notices of the Royal Astronomical Society, 2011
Accepted by MNRAS main ...
Ramsay, G, Napiwotzki, R, Barclay, T, Hakala, P, Potter, S, Cropper, M   +5 more
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

photoD with Rubin’s Data Preview 1: First stellar photometric distances and faint blue star deficits

Astronomy & Astrophysics
Aims. We investigate the utility of Rubin’s Data Preview 1 (DP1) for estimating stellar number density profiles across the Milky Way halo. Methods.
Palaversa L., Donev E., Ivezić Ž., Mrakovčić K., Caplar N., Jurićc M., Jurkić T., Campos S., DeLucchi M., Jones D., Malanchev K., Malz A. I., McGuire S., Abel B., Girardi L., Pastorelli G., Trabucchi M., Zaggia S., Acosta E., Adair C. L., Andrew J., Aubourg É., Bauer A. E., Beebe W., Bellm E. C., Blum R. D., Booth M. T., Boucaud A., Branton D., Burke D. L., Calabrese D., Carlin J. L., Chiang H.-F., Choi Y., Connolly A. J., Dagoret-Campagne S., Daly P. N., Daruich F., Daubard G., Dennihy E., Drass H., Eiger O., Eisner A. M., Guy L. P., Hoblitt J., Ingraham P., Jammes F., Jannuzi B. T., Jee M. J., Jenness T., Jones R. L., Juramy-Gilles C., Kahn S. M., Kang Y., Kannawadi A., Kelvin L. S., Kotov I. V., Kovács G., Kurita N. R., Lange T., Laporte D., Lazarte J. C., Liang S., Lopez M., Lust N. B., Lutfi M., Lynn O., Mainetti G., Menanteau F., Miller M., Moniez M., Nourbakhsh E., Park H. Y., Peterson J. R., Plante R., Plazas Malagón A. A., Porter M. N., Reil K. A., Riot V. J., Roodman A., Rykoff E. S., Schindler R. H., Sebag J., Sedaghat N., Shaw R. A., Shugart A., Siruno K. B., Smith J. A., Swinbank J. D., Thayer J. G., Thomas S., Tighe R., Tucker D. L., Turri M., Urbach E. K., Van Klaveren B., van Reeven W., Waters C. Z., Willman B.   +98 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A Deep, High-angular-resolution 3D Dust Map of the Southern Galactic Plane

The Astrophysical Journal
We present a deep, high-angular-resolution 3D dust map of the southern Galactic plane over 239° 
Catherine Zucker, Andrew K. Saydjari, Joshua S. Speagle, Edward F. Schlafly, Gregory M. Green, Robert Benjamin, Joshua Peek, Gordian Edenhofer, Alyssa Goodman, Michael A. Kuhn, Douglas P. Finkbeiner   +10 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Spatially Resolved Analysis of Stellar Populations in NGC 2992: Impact of Active Galactic Nucleus Feedback

The Astrophysical Journal
In NGC 2992, a galaxy-scale ionized gas outflow driven by active galactic nuclei (AGNs) has long been recognized, yet its impact on the host galaxy has remained elusive.
Xiaoyu Xu, Junfeng Wang, Zhiyuan Li, Yanmei Chen   +3 more
doaj   +1 more source

Important considerations of Stellar distance indicators

, 2020
Periodic luminous pulses are very important for measurements in Cosmology and Astrophysics, and there are very specific methods and sources which exhibit such properties. Stellar astrophysics provides a number of observational and mathematical sources which give a very important tool in understanding the dynamics of an expanding Universe, and in this ...
openaire   +2 more sources

Gaia, Stellar Populations and the Distance Scale

, 2018
We discuss the impact that Gaia, a European Space Agency (ESA) cornerstone mission that has been in scientific operations since July 2014, is expected to have on the definition of the cosmic distance ladder and the study of resolved stellar populations in and beyond the Milky Way, specifically focusing on results based on Cepheids and RR Lyrae stars ...
Clementini, Gisella, Garofalo, Alessia, Muraveva, Tatiana, Ripepi, Vincenzo   +3 more
openaire   +2 more sources