Results 111 to 120 of about 112,637 (293)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Magnetic Webs in Stellar Radiative Zones

The Astrophysical Journal Letters
Rotational evolution of stellar radiative zones is an old puzzle. We argue that angular momentum transport by turbulent processes induced by differential rotation is insufficient, and propose that a key role is played by “magnetic webs.” We define ...
Valentin A. Skoutnev, Andrei M. Beloborodov   +1 more
doaj   +1 more source

Stellar dynamics of blue compact galaxies: I. Decoupled star-gas kinematics in ESO 400-G43 [PDF]

, 2004
Göran Östlin, Robert Cumming, P. Amram, N. Bergvall, D. Kunth, I. Márquez, J. Masegosa, Erik Zackrisson   +7 more
openalex   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Stellar and gas dynamics of late-type barred-spiral galaxies: NGC 3359, a test case [PDF]

, 2009
P. A. Patsis, D. E. Kaufmann, S. T. Gottesman, V. Boonyasait   +3 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

A Novel Approach to Identifying Substructures through Analysis of Metallicity Distribution Functions

The Astrophysical Journal
We present a new method for identifying Galactic halo substructures accreted from dwarf galaxies by combining metallicity distribution functions (MDFs) with orbital parameters.
Young Kwang Kim, Young Sun Lee, Timothy C. Beers   +2 more
doaj   +1 more source

SMALL SCATTER AND NEARLY ISOTHERMAL MASS PROFILES TO FOUR HALF-LIGHT RADII FROM TWO-DIMENSIONAL STELLAR DYNAMICS OF EARLY-TYPE GALAXIES [PDF]

, 2015
Michele Cappellari, Aaron J Romanowsky, Jean P. Brodie, Duncan A Forbes, Jay Strader, Caroline Foster, Sreeja S. Kartha, Nicola Pastorello, Vincenzo Pota, Lee R. Spitler, Christopher Usher, Jacob A. Arnold   +11 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Mass Ejection Driven by Sudden Energy Deposition in Stellar Envelopes

The Astrophysical Journal
A number of stellar astrophysical phenomena, such as tidal novae and planetary engulfment, involve sudden injection of subbinding energy in a thin layer within the star, leading to mass ejection of the stellar envelope.
Nicholas J. Corso, Dong Lai
doaj   +1 more source