Results 121 to 130 of about 3,529,940 (309)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

StarStream: Automatic Detection Algorithm for Stellar Streams

The Astrophysical Journal
The Gaia mission has led to the discovery of over 100 stellar streams in the Milky Way, most of which likely originated from globular clusters (GCs).
Yingtian Chen, Oleg Y. Gnedin, Adrian M. Price-Whelan, Colin Holm-Hansen   +3 more
doaj   +1 more source

Probing Stellar Dynamics in Galactic Nuclei

, 2009
Electromagnetic observations over the last 15 years have yielded a growing appreciation for the importance of supermassive black holes (SMBH) to the evolution of galaxies, and for the intricacies of dynamical interactions in our own Galactic center. Here
Alexander, Tal, Amaro-Seoane, Pau, Barth, Aaron J., Cutler, Curt, Gair, Jonathan R., Hopman, Clovis, Merritt, David, Miller, M. Coleman, Phinney, E. Sterl, Richstone, Douglas O.   +9 more
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Probing Stellar Kinematics with the Time-Asymmetric Hanbury Brown and Twiss Effect

The Open Journal of Astrophysics
Intensity interferometry (II) offers a powerful means to observe stellar objects with a high resolution. In this work, we demonstrate that II can also probe internal stellar kinematics by revealing a time-asymmetric Hanbury Brown and Twiss (HBT) effect ...
Lucijana Stanic, Ivan Cardea, Edoardo Charbon, Domenico Della Volpe, Daniel Florin, Andrea Guerrieri, Gilles Koziol, Etienne Lyard, Nicolas Produit, Aramis Raiola, Prasenjit Saha, Vitalii Sliusar, Achim Vollhardt, Roland Walter   +13 more
doaj   +1 more source

Merging stellar-mass binary black holes

, 2018
The LIGO and Virgo detectors have recently directly observed gravitational waves from several mergers of pairs of stellar-mass black holes, as well as from one merging pair of neutron stars.
Farmer, Alison, Mandel, Ilya
core  

The SL2S Galaxy-scale Lens Sample. V. Dark Matter Halos and Stellar IMF of Massive Early-type Galaxies out to Redshift 0.8

, 2014
We investigate the cosmic evolution of the internal structure of massive early-type galaxies over half of the age of the Universe. We perform a joint lensing and stellar dynamics analysis of a sample of 81 strong lenses from the SL2S and SLACS surveys ...
Auger, Matthew W., Gavazzi, Raphael, Marshall, Philip J., Nipoti, Carlo, Sonnenfeld, Alessandro, Suyu, Sherry H., Treu, Tommaso   +6 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The Collision and Merger Products of Stars Do Not Look Alike: A Magnetohydrodynamics Comparison

The Astrophysical Journal
A significant fraction of stars experience close interactions, including collisions resulting from gravitational encounters and mergers within close binary systems.
Pavan Vynatheya, Taeho Ryu, Chen Wang, Alison Sills, Rüdiger Pakmor   +4 more
doaj   +1 more source