Results 121 to 130 of about 112,637 (293)

Regular and Chaotic Dynamics of Triaxial Stellar Systems [PDF]

open access: bronze, 1998
Monica Valluri   +3 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Milky Way Mass Through Escape Velocity Curve from LAMOST K Giants

open access: yesThe Astrophysical Journal
Escape velocity has long been used to constrain the mass of the dark matter (DM) halo in the Milky Way (MW). Here, we present a study of the escape velocity curve using a sample of high-velocity K giants with full 6D phase-space information and of ...
Yin Wu   +4 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Dark Galactic Subhalos and the Gaia Snail

open access: yesThe Astrophysical Journal
Gaia has revealed a clear signal of disequilibrium in the solar neighborhood in the form of a spiral (or snail) feature in the vertical phase-space distribution.
Daniel Gilman   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Tracing the Galactic Origins of Selected Four G-type Stars in the Solar Neighborhood

open access: yesThe Astronomical Journal
We present a multimethod investigation of four metal-poor G-type main-sequence stars to resolve their Galactic origins. By combining high-resolution spectroscopy from PolarBase, photometric/astrometric data from Gaia DR3, and spectral energy distribution
Deniz Cennet Çınar   +3 more
doaj   +1 more source

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