Results 131 to 140 of about 112,637 (293)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
KRIOS: A new basis-expansion $N$-body code for collisional stellar dynamics [PDF]
Kerwann Tep +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
The Escape Velocity Profile of the Milky Way from Gaia DR3
The Astrophysical JournalThe escape velocity profile of the Milky Way offers a crucial and independent measurement of its underlying mass distribution and dark matter (DM) properties.
Cian Roche +4 more
doaj +1 more source
Ground-based monitoring of the variability of visible Solar spectral lines for improved understanding of solar and stellar magnetism and dynamics [PDF]
, 2023 S. Criscuoli +9 more
openalex +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Collisional Shaping of Nuclear Star Cluster Density Profiles
The Astrophysical Journal LettersA supermassive black hole surrounded by a dense, nuclear star cluster resides at the center of many galaxies. In this dense environment, high-velocity collisions frequently occur between stars.
Sanaea C. Rose, Morgan MacLeod
doaj +1 more source
A stellar census in globular clusters with MUSE: The contribution of rotation to cluster dynamics studied with 200 000 stars [PDF]
, 2017 Sebastian Kamann +12 more
openalex +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source