Results 111 to 120 of about 744 (246)

Risk factors for relapse in ANCA‐associated vasculitis among patients with relapse after induction of remission with rituximab

Arthritis &Rheumatology, Accepted Article.
Objective To determine risk factors for relapse of ANCA‐associated vasculitis (AAV) after re‐induction of remission with rituximab and discontinuation of maintenance therapy. Methods This is a post‐hoc analysis of the RITAZAREM clinical trial. Patients 15 years or older with AAV and a positive test for anti‐proteinase‐3 (PR3‐) or anti‐myeloperoxidase ...
Ellen Romich, Joshua F. Baker, Thomas R. Riley IV, Ian Green, Rennie L. Rhee, Carol A. McAlear, Ulrich Specks, Rona M. Smith, David R. Jayne, Peter A. Merkel, for the RITAZAREM Investigators   +10 more
wiley   +1 more source

Molecular Hydrogen Controls the Temperatures of Flares on TRAPPIST-1

The Astrophysical Journal Letters
Early JWST observations of TRAPPIST-1 have revealed an unexpected puzzle: energetic white-light flares ( E  > 10 ^30 erg) reach temperatures of only ∼3500–4000 K, nearly 3 times cooler than typical solar flares, which peak around 9000–10,000 K.
A. I. Shapiro, N. Kostogryz, S. Seager, V. Witzke, J. de Wit, V. Vasilyev, Astrid M. Veronig, Cameron Robert, Peter Hardi, S. K. Solanki   +9 more
doaj   +1 more source

Efficacy and Safety of Subcutaneous Anifrolumab in Systemic Lupus Erythematosus: A Randomized, Phase 3 Study

Arthritis &Rheumatology, EarlyView.
Objective The multinational, phase 3, double‐blind, placebo‐controlled TULIP‐SC trial evaluated the efficacy and safety of subcutaneous anifrolumab in adults who have moderate to severe systemic lupus erythematosus (SLE) activity, despite receiving standard therapy. Methods Adults with SLE received subcutaneous anifrolumab 120 mg or placebo once weekly
Susan Manzi, Ian N. Bruce, Eric F. Morand, Richard Furie, Yoshiya Tanaka, Kenneth C. Kalunian, Anca Askanase, Patricia Puzio, Emon Khan, Jenny Wissmar, Michael Song, Catharina Lindholm, for the TULIP‐SC investigators   +12 more
wiley   +1 more source

Probing Starspot Dynamics on the Active M Dwarf TIC 272272592: A Multiyear TESS Study

The Astrophysical Journal
We present an analysis of temporal starspot evolution and its distribution on an active rapid rotator ( P _rot = 1.22 days), TIC 272272592, using high-precision time-series photometry from the Transiting Exoplanet Survey Satellite spanning over 3 yr. The
Rajib Kumbhakar, Soumen Mondal, Samrat Ghosh, Diya Ram, Dorothy M. Mwanzia   +4 more
doaj   +1 more source

The Effect of Intranasal Niclosamide on Nasal Symptoms in Patients with Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Ear, nose, and throat (ENT) manifestations are common in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). There is an unmet need for drugs to target these manifestations. Granuloma formation is characteristic of proteinase 3 (PR3)–AAV. In a zebrafish model, niclosamide inhibits PR3‐induced granuloma formation.
Benjamin Lim, Wendi Qian, Francis Dowling, Alan Salama, Rona M Smith   +4 more
wiley   +1 more source

Effect of Time-varying X-Ray Emission from Stellar Flares on the Ionization of Protoplanetary Disks

The Astrophysical Journal
X-rays have significant impacts on cold, weakly ionized protoplanetary disks by increasing the ionization rate and driving chemical reactions. Stellar flares are explosions that emit intense X-rays and are the unique source of hard X-rays with an energy ...
Haruka Washinoue, Shinsuke Takasao, Kenji Furuya   +2 more
doaj   +1 more source

Multi-Observatory Research of Young Stellar Energetic Flares (MORYSEF): X-Ray-flare-related Phenomena and Multi-epoch Behavior

The Astrophysical Journal
The most powerful stellar flares driven by magnetic energy occur during the early pre-main-sequence (PMS) phase. The Orion Nebula represents the nearest region populated by young stars, showing the greatest number of flares accessible to a single ...
Konstantin V. Getman, Eric D. Feigelson, Abygail R. Waggoner, L. Ilsedore Cleeves, Jan Forbrich, Joe P. Ninan, Oleg Kochukhov, Vladimir S. Airapetian, Sergio A. Dzib, Charles J. Law, Christian Rab   +10 more
doaj   +1 more source

Impact of Early Antimalarial Adherence on Future Acute Care Utilization and Cost Among Patients With Rheumatoid Arthritis and Systemic Lupus Erythematosus: A Population‐Based Study

Arthritis &Rheumatology, EarlyView.
Objective To assess the association between early antimalarial adherence and future acute care utilization and cost in a population‐based cohort of incident rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Methods All patients with incident RA/SLE and new antimalarial use in British Columbia, Canada, between January 1997 and March 2022
Md Rashedul Hoque, Diane Lacaille, J. Antonio Aviña‐Zubieta, Mary A. De Vera, Yi Qian, Lawrence McCandless, John M. Esdaile, Hui Xie   +7 more
wiley   +1 more source

Stellar Flares and Coronal Structure

, 2003
Coronal structure and coronal heating are intimately related in magnetically active stars. Coronal structure is commonly inferred from radio interferometry and from eclipse and rotational modulation studies. We discuss to what extent flares may be responsible for coronal structure and global observable properties in magnetically active stars.
openaire   +2 more sources

Anifrolumab Treatment Leads to Rapid Reduction in Urinary Biomarkers of Intrarenal Inflammation in Lupus Nephritis: Results from the Phase 2 TULIP‐LN Trial

Arthritis &Rheumatology, Accepted Article.
Objectives Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE) and is partially driven by type I interferon (IFN) signaling. Anifrolumab, an approved treatment for patients with SLE, has been investigated in a phase 2 trial in patients with LN receiving standard therapy (TULIP‐LN, NCT02547922). We studied
Andrea Fava, Michelle Petri, Patrick G. Gavin, Eszter Csomor, Philip Z. Brohawn, Daniel Muthas, Adam Platt, Catharina Lindholm, Nicola Ferrari   +8 more
wiley   +1 more source