Results 201 to 210 of about 744 (246)

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Probing the transient and time-variable sky. [PDF]

Open Res Eur
Orlowski-Scherer J, Maccarone T, Bright J, Kamiński T, Koss M, Mohan A, Miguel Montenegro-Montes F, Næss S, Ricci C, Severgnini P, Stanke T, Vignali C, Wedemeyer S, Booth M, Cicone C, Di Mascolo L, Johnstone D, Mroczkowski T, Cordiner M, Greiner J, Hatziminaoglou E, van Kampen E, Klaassen P, Lee M, Liu D, Saintonge A, Smith M, Thelen A.   +27 more
europepmc   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

An Earth-sized exoplanet ripe for emission spectroscopy with JWST in orbit around a nearby ultracool dwarf star

, 2023
Gillon M, Pedersen P, Rackham B, Dransfield G, Ducrot E, Barkaoui K, Burdanov A, Schroffenegger U, Chew YGM, Lederer S, Alonso R, Burgasser A, Howell S, Narita N, de Wit J, Demory B, Queloz D, Triaud A, Delrez L, Jehin E, Hooton M, Garcia L, Munoz CJ, Murray C, Pozuelos F, Sebastian D, Timmermans M, Thompson S, Zuniga-Fernandez S, Aceituno J, Aganze C, Amado P, Benkhaldoun Z, Bolmont É, Clark C, Davoudi F, de Leon J, Ikoma M, Ikuta K, Isogai K, Fukuda I, Fukui A, Gerasimov R, Ghachoui M, Hayashi Y, Hu R, Kagetani T, Kawai Y, Kawauchi K, Koll D, Livingston J, Lyu X, Mori M, Murgas F, Palle E, Rebolo R, Selsis F, Sota A, Stassun K, Tamura M, Theissen C, Turbet M, Grootel VV, Varas R, Watanabe N.   +64 more
europepmc   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

On the Instrumental Discrepancies in Lyman-Alpha Observations of Solar Flares. [PDF]

Sol Phys
Greatorex HJ, Milligan RO, Dammasch IE.
europepmc   +1 more source

Long‐term remission in gout: Challenges and future opportunities

Rheumatology &Autoimmunity, EarlyView.
Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley   +1 more source

Impact of Allostatic Load on Chronic Hepatitis B and C: A Narrative Review. [PDF]

Cureus
Ogbu CE, Kalu JN, Ezechukwu M, Umerah C.
europepmc   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Challenges and opportunities for time-delay cosmography with multi-messenger gravitational lensing. [PDF]

Philos Trans A Math Phys Eng Sci
Birrer S, Smith GP, Shajib AJ, Ryczanowski D, Arendse N.   +4 more
europepmc   +1 more source