Results 221 to 230 of about 22,322 (295)

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Perspectives on the physics of late-type stars from beyond low earth orbit, the moon and mars. [PDF]

NPJ Microgravity
Mathur S, Santos ÂRG.
europepmc   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Magnetic star-planet interaction in the young exoplanet system DS Tucanae Ab

Santos Ld, Owen J, Duvvuri G, Loyd ROP, Vidotto A, Presa A, Bourrier V, King G, Airapetian V, Ehrenreich D, France K, Lendl M, Lothringer J, Nielsen L.   +13 more
europepmc   +1 more source

Lense-Thirring precession after a supermassive black hole disrupts a star. [PDF]

Nature
Pasham DR, Zajaček M, Nixon CJ, Coughlin ER, Śniegowska M, Janiuk A, Czerny B, Wevers T, Guolo M, Ajay Y, Loewenstein M.   +10 more
europepmc   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Exploring the sub-Neptune frontier with JWST. [PDF]

Proc Natl Acad Sci U S A
Madhusudhan N, Holmberg M, Constantinou S, Cooke GJ.   +3 more
europepmc   +1 more source

Multiple outflows and delayed ejections revealed by early imaging of novae. [PDF]

Nat Astron
Aydi E, Monnier JD, Mérand A, Schaefer GH, Chomiuk L, Otulakowska-Hypka M, Fan JL, Li KL, Sokolovsky KV, Salinas R, Tucker M, Shappee B, Rudy R, Page KL, Kuin NPM, Buckley DAH, Craig P, Izzo L, Linford J, Metzger BD, Mukai K, Orio M, Shen KJ, Strader J, Sokoloski JL, Williams RE, Williams MN, Habtie GR, Kraus S, Anugu N, Bouquin JL, Chhabra S, Codron I, Gardner T, Gutierrez M, Ibrahim N, Lanthermann C, Setterholm BR, Ashall C, Hinkle JT, Jaeger T, Payne AV.   +41 more
europepmc   +1 more source