Results 261 to 270 of about 2,433 (297)

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Magnetic, thermal and rotational evolution of isolated neutron stars. [PDF]

Living Rev Comput Astrophys
Pons JA, Dehman C, Viganò D.
europepmc   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Impact of Allostatic Load on Chronic Hepatitis B and C: A Narrative Review. [PDF]

Cureus
Ogbu CE, Kalu JN, Ezechukwu M, Umerah C.
europepmc   +1 more source

Precise Masses Reveal that TOI-700 c is Low Density and TOI-700 d is Rocky

Gilbert E, Burt J, Barragán O, Siegel J, Mascareño AS, Silva A, Luque R, Rogers J, Lee E, Lopez E, Vanderburg A, Clement M, Youngblood A, Mamajek E, Sousa S, Cameron AC, Rodriguez J, Martin D, Arney G, Barclay T, Becker J, Colon K, Eisner N, Halverson S, Hord B, Kane S, Kreidberg L, Morley C, Mortier A, Nielsen L, Quintana E, Schlieder J, Suissa G, Triaud A, Trifonov T, Eylen VV.   +35 more
europepmc   +1 more source

Outstanding Questions and Future Research on Magnetic Reconnection. [PDF]

Space Sci Rev
Nakamura R, Burch JL, Birn J, Chen LJ, Graham DB, Guo F, Hwang KJ, Ji H, Khotyaintsev YV, Liu YH, Oka M, Payne D, Sitnov MI, Swisdak M, Zenitani S, Drake JF, Fuselier SA, Genestreti KJ, Gershman DJ, Hasegawa H, Hoshino M, Norgren C, Shay MA, Shuster JR, Stawarz JE.   +24 more
europepmc   +1 more source

Multi-messenger gravitational lensing. [PDF]

Philos Trans A Math Phys Eng Sci
Smith GP, Baker T, Birrer S, Collins CE, Ezquiaga JM, Goyal S, Hannuksela OA, Hemanta P, Hendry MA, Janquart J, Keitel D, Levan AJ, Lo RKL, More A, Nicholl M, Pastor-Marazuela I, Ponte Pérez AI, Ubach H, Uronen LE, Wright M, Zumalacarregui M, Bianco F, Çalişkan M, Chan JCL, Colangeli E, Gompertz BP, Haines CP, Hayes EE, Hu B, Lamb GP, Liu A, Mandhai S, Narola H, Nguyen QL, Poon JSC, Ryczanowski D, Seo E, Shajib AJ, Shan X, Tanvir N, Vujeva L.   +40 more
europepmc   +1 more source

An Abrupt Change in the Disk Fraction of Free-Floating Planets at the Deuterium-Burning Ignition Limit

Rodrigues T, Bouy H, Raymond S, Martín E, Bertin E, Romero JO, Barrado D, Huélamo N, Tamura M, Roig NM, Galli P, Cuillandre J.   +11 more
europepmc   +1 more source

Optimizing photosynthetic light-harvesting under stars: Generalized thermodynamic models

Chitnavis S, Gray C, Rousouli I, Gillen E, Mullineaux CW, Haworth TJ, Duffy CDP.   +6 more
europepmc   +1 more source