Results 61 to 70 of about 3,488,609 (297)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Magnetic Fields in a Sample of Planet-hosting M Dwarf Stars from Kepler, K2, and TESS Observed by APOGEE

The Astrophysical Journal
Stellar magnetic fields have a major impact on space weather around exoplanets orbiting low-mass stars. From an analysis of Zeeman-broadened Fe i lines measured in near-infrared SDSS/APOGEE spectra, mean magnetic fields are determined for a sample of 29 ...
Fábio Wanderley, Katia Cunha, Verne V. Smith, Oleg Kochukhov, Diogo Souto, C. Allende Prieto, Suvrath Mahadevan, Steven R. Majewski, Philip S. Muirhead, Marc Pinsonneault, Ryan Terrien   +10 more
doaj   +1 more source

The large-scale magnetic fields of planet-hosting solar-type stars [PDF]

, 2017
Stellar magnetic fields and their associated phenomena influence stellar behaviour and evolution, and potentially have significant impacts on any surrounding planetary system.
Mengel, Matthew W.
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Saturation of the Large-scale Magnetic Field for Fast Rotating Solar-like Stars Driven by Inefficient Turbulent Angular Momentum Transport

The Astrophysical Journal
Magnetic activity in solar-like stars shows a systematic dependence on stellar rotation rate, known as the “activity–rotation relationship.” Recent observations further reveal that large-scale surface magnetic fields in solar-like stars are ...
Ryota Shimada, Takaaki Yokoyama
doaj   +1 more source

Relationships Between Solar and Stellar Magnetic Fields [PDF]

Symposium - International Astronomical Union, 1983
Observational and theoretical studies of solar and stellar magnetic fields are reviewed. The discussion draws together several themes that emerged during IAU Symposium 102 on “Solar and Stellar Magnetic Fields: Origins and Coronal Effects,” and identifies a number of areas in which research over the next few years is likely to be fruitful.
openaire   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Magnetic Fields in Stellar Astrophysics

, 2009
This is a white paper submitted to the Stars and Stellar Evolution (SSE) Science Frontier Panel (SFP) of the NRC's 2010 Astronomy and Astrophysics Decadal Survey. The white paper is endorsed by the NSF Physics Frontier Center for Magnetic Self-Organization in Laboratory and Astrophysical Plasmas (CMSO).
Uzdensky, Dmitri, Forest, Cary, Ji, Hantao, Townsend, Richard, Yamada, Masaaki   +4 more
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The Importance of Ambipolar Heating in the Standard Thin Accretion Disk with Outflows

The Astrophysical Journal
This study examines the importance of the thermal effects of ambipolar diffusion (AD), by analyzing the governing properties in the middle and outer regions of a standard thin accretion disk with outflows.
Mahmoud Gholipour, Amir Abbas Eslami Shafigh   +1 more
doaj   +1 more source