Results 41 to 50 of about 3,312,921 (291)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Consequences of spontaneous reconnection at a two-dimensional non-force-free current layer [PDF]

, 2012
Magnetic neutral points, where the magnitude of the magnetic field vanishes locally, are potential locations for energy conversion in the solar corona.
E. R. Priest, Hood, Alan William, Parnell, Clare Elizabeth, Priest, Eric Ronald, Longcope, Dana, J. Fuentes-Fernández, C. E. Parnell, A. W. Hood, Fuentes Fernandez, Jorge, D. W. Longcope   +9 more
core   +1 more source

The rotation–magnetism relationship in solar-type stars

Astronomy & Astrophysics
Context. The rotation–activity relationship of G-type stars results from surface magnetic fields emerging from the interior. How the magnetic flux and its emergence rate scale with rotation rate are not well understood, both observationally and ...
Işık Emre, Solanki Sami K., Krivova Natalie A., Shapiro Alexander I.   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Simplified Model of the Solar Magnetic Field

The Astrophysical Journal
This paper considers a structure consisting of two rings of magnetic dipoles symmetrical relative to the equatorial plane as a possible model for the source of the solar magnetic field.
Igor G. Kosakovskij
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Magnetic Fields in M-dwarf Members of the Pleiades Open Cluster Using APOGEE Spectra

The Astrophysical Journal
Average magnetic field measurements are presented for 62 M-dwarf members of the Pleiades open cluster, derived from Zeeman-enhanced Fe i lines in the H band.
Fábio Wanderley, Katia Cunha, Oleg Kochukhov, Verne V. Smith, Diogo Souto, Lyra Cao, Kevin Covey, Steven R. Majewski, Cintia Martinez, Philip S. Muirhead, Marc Pinsonneault, C. Allende Prieto, Keivan G. Stassun   +12 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Effects of M dwarf magnetic fields on potentially habitable planets [PDF]

, 2013
A.A.V. acknowledges support from the Royal Astronomical Society through a post-doctoral fellowship. J.M. acknowledges support from a fellowship of the Alexander von Humboldt foundation. P.L. acknowledges funding from a STFC scholarship.
Morin, J., J.-F. Donati, Russell, A.J.B., P. Lang, Donati, J. -F., Jardine, M., A. A. Vidotto, M. Jardine, Morin, Julien, Donati, J.-F., Lang, P., Vidotto, A. A., Russell, A. J. B., Donati, J., Vidotto, A., A. J. B. Russell, J. Morin, Vidotto, A.A., Russell, A., J. -f. Donati   +19 more
core   +1 more source

Stellar dynamics: Rotation, convection, and magnetic fields [PDF]

, 2015
Stars are changing entities in a constant evolution during their lives. At non-secular time scales (from seconds to years) the effect of dynamical processes such as convection, rotation, and magnetic fields can modify the stellar oscillations. Convection excites acoustic modes in solar-like stars, while rotation and magnetic fields can perturb the ...
Mathur, S., Ballot, J., Garcia, R. A.
openaire   +2 more sources