Results 161 to 170 of about 284,450 (301)

Evidence that Mass Loss on the Red Giant Branch Decreases with Metallicity

The Astrophysical Journal
Mass loss on the red giant branch (RGB) influences stellar evolution, properties of stellar populations, and Galactic chemical enrichment, yet remains poorly constrained observationally. Current models provide limited insight into how stellar properties,
Yaguang Li
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Large Dark Matter Content and Steep Metallicity Profile Predicted for Ultradiffuse Galaxies Formed in High-spin Halos

The Astrophysical Journal
We study the stellar properties of a sample of simulated ultradiffuse galaxies (UDGs) with stellar mass M _⋆ = 10 ^7.5 –10 ^9 M _⊙ , selected from the TNG50 simulation, where UDGs form mainly in high-spin dwarf-mass halos.
José A. Benavides, Laura V. Sales, Mario. G. Abadi, Mark Vogelsberger, Federico Marinacci, Lars Hernquist   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Constraining the Stellar-to-Halo Mass Relation with Galaxy Clustering and Weak Lensing from DES Year 3 Data

The Open Journal of Astrophysics
We develop a framework to study the relation between the stellar mass of a galaxy and the total mass of its host dark matter halo using galaxy clustering and galaxy-galaxy lensing measurements. We model a wide range of scales, roughly from $\sim 100 \; {\
G. Zacharegkas, C. Chang, J. Prat, W. Hartley, S. Mucesh, A. Alarcon, O. Alves, A. Amon, K. Bechtol, M. R. Becker, G. Bernstein, J. Blazek, A. Campos, A. Carnero Rosell, M. Carrasco Kind, R. Cawthon, R. C. Chen, A. Choi, J. Cordero, C. P. Davis, J. DeRose, H. Diehl, S. Dodelson, C. Doux, A. Drlica-Wagner, K. Eckert, T. F. Eifler, J. Elvin-Poole, S. Everett, X. Fang, A. Ferte, M. Gatti, G. Giannini, D. Gruen, R. A. Gruendl, I. Harrison, H. Huang, E. M. Huff, M. Jarvis, E. Krause, N. Kuropatkin, P. F. Leget, N. MacCrann, J. McCullough, J. Myles, A. N. Alsina, S. Pandey, M. Raveri, R. P. Rollins, A. Roodman, A. J. Ross, E. Rykoff, C. Sánchez, L. F. Secco, I. Sevilla-Noarbe, E. Sheldon, T. Shin, M. A. Troxel, I. Tutusaus, B. Yanny, B. Yin, Y. Zhang, J. Zuntz, M. Aguena, F. Andrade-Oliveira, D. Bacon, D. Brooks, D. L. Burke, J. Carretero, F. J. Castander, L .N. da Costa, M. E. da Silva Pereira, T. M. Davis, J. De Vicente, B. Flaugher, J. Frieman, J. Garcia-Bellido, E. Gaztañaga, G. Gutierrez, S. R. Hinton, D. L. Hollowood, D. J. James, K. Kuehn, O. Lahav, S. Lee, J. L. Marshall, J. Mena-Fernandez, R. Miquel, J. J. Mohr, R. L. C. Ogando, A. A. Plazas Malagon, A. Porredon, S. Samuroff, E. Sanchez, M. Smith, M. Soares-Santos, E. Suchyta, M. E. C. Swanson, D. L. Tucker, V. Vikram, N. Weaverdyck, P. Wiseman, M. Yamamoto   +102 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Synthetic stellar mass-to-light ratios for stellar populations

, 1998
Evolutionary synthesis models for stellar populations of various ages and chemical compositions are constructed with the approach described in Maraston (1998), in which the Fuel Consumption Theorem is used to evaluate the energetics of Post Main Sequence stars.
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Low-Mass Binaries and Stellar Dynamos [PDF]

The Astrophysical Journal, 1996
Muslimov, A., Sarna, M.J.
openaire   +3 more sources

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source