Results 141 to 150 of about 284,450 (301)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Coevolution of Nuclear Star Clusters and Massive Black Holes: Extreme-mass-ratio Inspirals

The Astrophysical Journal
We explore extreme-mass-ratio inspirals (EMRIs) in the coevolution of massive black holes (MBHs) and nuclear star clusters (NSCs), which host diverse stellar populations across a wide range of masses. The dynamics are simulated self-consistently with GNC
Fupeng Zhang, Pau Amaro Seoane
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Exploring the Evolution of a Dwarf Spheroidal Galaxy with Smoothed-particle Hydrodynamics Simulations. I. Stellar Feedback

The Astrophysical Journal
A fundamental question regarding the evolution of dwarf spheroidal galaxies is the identification of the key physical mechanisms responsible for gas depletion.
Roberto Hazenfratz, Paramita Barai, Gustavo A. Lanfranchi, Anderson Caproni   +3 more
doaj   +1 more source

The z = 9.625 Cosmic Gems galaxy was a compact “blue monster” propelled by massive star clusters★

Astronomy & Astrophysics
The recent discovery of five massive stellar clusters at z = 9.625 in the Cosmic Gems galaxy has raised the question about the formation mechanism of star clusters in the first 500 Myr after the Big Bang. We inferred the total stellar mass in clusters by
Vanzella E., Messa M., Adamo A., Loiacono F., Oguri M., Sharon K., Bradley L. D., Bergamini P., Meneghetti M., Claeyssens A., Welch B., Bradač M., Zanella A., Bolamperti A., Calura F., Hsiao T. Y.-Y., Zackrisson E., Ricotti M., Christensen L., Diego J. M., Bauer F. E., Xu X., Fujimoto S., Grillo C., Lombardi M., Rosati P., Resseguier T., Zitrin A., Bik A., Richard J., Abdurro’uf, Bhatawdekar R., Coe D., Frye B., Inoue A. K., Jimenez-Teja Y., Norman C., Rigby J. R., Trenti M., Hashimoto T.   +39 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A Census of Star Formation Histories of Massive Galaxies at 0.6 < z < 1 from Spectrophotometric Modeling Using Bagpipes and Prospector

The Astrophysical Journal
We present individual star formation histories (SFHs) of ∼3000 massive galaxies (log( M _* / M _⊙ ) > 10.5) from the Large Early Galaxy Astrophysics Census spectroscopic survey at a lookback time of ∼7 billion yr and quantify the population trends ...
Yasha Kaushal, Angelos Nersesian, Rachel Bezanson, Arjen van der Wel, Joel Leja, Adam Carnall, Anna Gallazzi, Stefano Zibetti, Gourav Khullar, Marijn Franx, Adam Muzzin, Anna de Graaff, Camilla Pacifici, Katherine E. Whitaker, Eric F. Bell, Marco Martorano   +15 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

An Early Dark Matter–dominated Phase in the Assembly History of Milky Way–mass Galaxies Suggested by the TNG50 Simulation and JWST Observations

The Astrophysical Journal Letters
Whereas well-studied galaxies at cosmic noon are found to be baryon dominated within the effective radius, recent JWST observations of z ∼ 6–7 galaxies with stellar masses of only M _* ∼ 10 ^8−9 M _⊙ surprisingly indicate that they are dark matter ...
Anna de Graaff, Annalisa Pillepich, Hans-Walter Rix   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source