Results 121 to 130 of about 55,503 (265)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Astrophysical JournalRecent observations suggest that the extended stellar halos of low-redshift massive galaxies are tightly connected to the assembly of their dark matter halos.
Shuo Xu +6 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Modelling and observations of molecules in discs around young stars [PDF]
, 2013 This thesis contains a study of molecules within circumstellar discs around young stars. Firstly, the chemistry of a disc around a young, Class 0 protostar is modelled.
Ilee, John David
core
The Astrophysical Journal LettersWhereas well-studied galaxies at cosmic noon are found to be baryon dominated within the effective radius, recent JWST observations of z ∼ 6–7 galaxies with stellar masses of only M _* ∼ 10 ^8−9 M _⊙ surprisingly indicate that they are dark matter ...
Anna de Graaff +2 more
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Stellar-mass black holes (3 M⊙≲MBH≲150 M⊙) are the natural product of the evolution of heavy stars (Mstar≳20 M⊙). In our Galaxy, we expect that 108–109 stellar-mass black holes have been formed from the
Cosimo Bambi
core +1 more source
Optical & X-ray Studies of Ultraluminous X-ray Sources [PDF]
, 2009 Ultraluminous X-ray Sources (ULXs) are point like X-ray sources situated external to the nucleus of their host galaxy, with inferred X-ray luminosities in excess of 10^{39} erg s^{−1} .
Gladstone, Jeanette Claire +1 more
core
Shooting for the Stars: Jet-mode Feedback and AGN Jet Deceleration from Stellar Mass Loading
The Astrophysical JournalActive Galactic Nucleus (AGN) jets are thought to be vital ingredients in galaxy evolution through the action of kinetic feedback; however, how narrow, relativistic outflows couple to galaxies remains an open question.
Talia M. O’Shea +4 more
doaj +1 more source