Results 101 to 110 of about 55,503 (265)

Stellar masses and mass ratios for Gaia open cluster members

Astronomy & Astrophysics
Context. Unresolved binaries in star clusters can bias stellar and cluster mass estimates. A proper treatment is therefore essential for studying the cluster dynamics and evolution. Aims.
Malhotra Sagar, Castro-Ginard Alfred, Anders Friedrich, Jordi Carme, Donada Judit, Luri Xavier, Balaguer-Núñez Lola, Qin Songmei, Jiang Yueyue, Župić Andrija   +9 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Modeling the Mass Distribution and Gravitational Potential of Nearby Disk Galaxies: Implications for the Interstellar Medium Dynamical Equilibrium

The Astrophysical Journal
We characterize stellar, gas, and dark matter mass distributions for 17 nearby massive disk galaxies from the PHANGS sample. This allows us to compute the gravitational potential that vertically confines the interstellar gas and determines its ...
Vivek Vijayakumar, Jiayi Sun, Eve C. Ostriker, Enrico M. Di Teodoro, Konstantin Haubner, Chang-Goo Kim, Adam K. Leroy, Miguel Querejeta   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Statistical Predictions of the Accreted Stellar Halos around Milky Way-Like Galaxies

The Open Journal of Astrophysics
In the $Λ$CDM paradigm, stellar halos form through the accretion and disruption of satellite galaxies. We introduce new semi-analytic modeling within the SatGen framework to track the ex-situ stellar components of Milky Way--like galaxies across large ...
J. Sebastian Monzon, Frank C. van den Bosch, Martin P. Rey   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Constraining the Stellar Mass Function in the Galactic Center via Mass Loss from Stellar Collisions

, 2019
The dense concentration of stars and high-velocity dispersions in the Galactic center imply that stellar collisions frequently occur. Stellar collisions could therefore result in significantmass loss rates.
Loeb, Abraham, Rubin, Douglas
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Young Stellar Clusters with a Schuster Mass Distribution - I: Stationary Winds

, 2013
Hydrodynamic models for spherically-symmetric winds driven by young stellar clusters with a generalized Schuster stellar density profile are explored. For this we use both semi-analytic models and 1D numerical simulations.
GUILLERMO TENORIO TAGLE, SERGIO MARTINEZ GONZALEZ, SERGIY SILICH   +2 more
core