Results 131 to 140 of about 55,503 (265)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

On the Signature of Black Holes on the Quenched Stellar Mass Function

The Astrophysical Journal
As star-forming galaxies approach or exceed a stellar mass of around 10 ^11 M _⊙ , they are increasingly likely to be quenched in a process generically called mass quenching.
Antonio J. Porras-Valverde, John C. Forbes   +1 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

CAST constraints on the axion-electron coupling

, 2013
In non-hadronic axion models, which have a tree-level axion-electron interaction, the Sun produces a strong axion flux by bremsstrahlung, Compton scattering, and axiorecombination, the "BCA processes." Based on a new calculation of this flux, including ...
Barth, Klaus, Belov, A., Hoffmann, D.H.H., Eleftheriadis, Christos, Miller, David W., Zioutas, K., Franz, Jürgen, Englhauser, J., Franz, J., Lakic, B., Villar, J., Gninenko, Sergei, Vieira, Joaquin D., Papaevangelou, Thomas, Riege, H., Ferrer-Ribas, E., Liolios, Anastasios, Walckiers, L., Walckiers, Louis, Kotthaus, R., Eleftheriadis, C., Belov, Alexander, Stewart, L., Pivovaroff, Mike J., Ruz, Jaime, Gómez, Héctor, Villar, José A., Davenport, Martyn, Luzón, Gloria, Jacoby, J., Semertzidis, Y., Königsmann, K., Heinsius, Fritz-Herbert, Savvidis, Ilias, Beltran, Berta, Hasinoff, M.D., Jacoby, Joachim, Vieira, J., Hoffmann, Dieter H. H., Giomataris, I., Vogel, J., Collar, J.I., García, J. A., Hasinoff, Michael D., Miller, D.W., Pivovaroff, M., Lutz, Gerhard, Carmona, J., Jakovcic, K., Jakovčić, Kresimir, Galan, J., Irastorza, I.G., Liolios, A., García, J., Ljubičić, Ante, Redondo, Javier, Friedrich, P., Heinsius, F.H., Collar, Juan I., Giomataris, Ioanis, Englhauser, Jakob, Vogel, Julia K., Kang, Donghwa, Bräuninger, Heinrich, Lutz, G., Fanourakis, G., Dafni, T., Villar, J.A., Krčmar, Milica, Bräuninger, H., Raffelt, G., Friedrich, Peter, Carmona, José Manuel, Di Lella, Luigi, Riege, Hans, Davenport, M., Rodríguez, A., Geralis, Theodoros, Kang, D., Stewart, Laura, Savvidis, I., Vieira, J.D., Fischer, H., Ljubicic, A., Pivovaroff, M.J., Galán, Javier, Collar, J., Fanourakis, George, Beltran, B., Ferrer-Ribas, Ester, Kuster, M., Luzon, G., Carmona, J.M., Papaevangelou, T., Miller, D., Irastorza, Igor Garcia, Zioutas, Konstantin, Ruz, J., Irastorza, I., Garcia, J.A., Hoffmann, D., Fischer, Horst, Dafni, Theopisti, Kousouris, Konstantinos, Raffelt, Georg, Heinsius, F., Kousouris, K., Van Bibber, K., Vogel, J.K., Barth, K., Hasinoff, M., Redondo, J., Di Lella, L., Krcmar, M., Königsmann, Kay, Gninenko, S., Lakić, Biljana, Bibber, Karl van, Gomez, H., Geralis, T., Kotthaus, Rainer, Semertzidis, Yannis   +121 more
core   +1 more source

Mass Ejection Driven by Sudden Energy Deposition in Stellar Envelopes

The Astrophysical Journal
A number of stellar astrophysical phenomena, such as tidal novae and planetary engulfment, involve sudden injection of subbinding energy in a thin layer within the star, leading to mass ejection of the stellar envelope.
Nicholas J. Corso, Dong Lai
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Large Dark Matter Content and Steep Metallicity Profile Predicted for Ultradiffuse Galaxies Formed in High-spin Halos

The Astrophysical Journal
We study the stellar properties of a sample of simulated ultradiffuse galaxies (UDGs) with stellar mass M _⋆ = 10 ^7.5 –10 ^9 M _⊙ , selected from the TNG50 simulation, where UDGs form mainly in high-spin dwarf-mass halos.
José A. Benavides, Laura V. Sales, Mario. G. Abadi, Mark Vogelsberger, Federico Marinacci, Lars Hernquist   +5 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Constraining the Stellar-to-Halo Mass Relation with Galaxy Clustering and Weak Lensing from DES Year 3 Data

The Open Journal of Astrophysics
We develop a framework to study the relation between the stellar mass of a galaxy and the total mass of its host dark matter halo using galaxy clustering and galaxy-galaxy lensing measurements. We model a wide range of scales, roughly from $\sim 100 \; {\
G. Zacharegkas, C. Chang, J. Prat, W. Hartley, S. Mucesh, A. Alarcon, O. Alves, A. Amon, K. Bechtol, M. R. Becker, G. Bernstein, J. Blazek, A. Campos, A. Carnero Rosell, M. Carrasco Kind, R. Cawthon, R. C. Chen, A. Choi, J. Cordero, C. P. Davis, J. DeRose, H. Diehl, S. Dodelson, C. Doux, A. Drlica-Wagner, K. Eckert, T. F. Eifler, J. Elvin-Poole, S. Everett, X. Fang, A. Ferte, M. Gatti, G. Giannini, D. Gruen, R. A. Gruendl, I. Harrison, H. Huang, E. M. Huff, M. Jarvis, E. Krause, N. Kuropatkin, P. F. Leget, N. MacCrann, J. McCullough, J. Myles, A. N. Alsina, S. Pandey, M. Raveri, R. P. Rollins, A. Roodman, A. J. Ross, E. Rykoff, C. Sánchez, L. F. Secco, I. Sevilla-Noarbe, E. Sheldon, T. Shin, M. A. Troxel, I. Tutusaus, B. Yanny, B. Yin, Y. Zhang, J. Zuntz, M. Aguena, F. Andrade-Oliveira, D. Bacon, D. Brooks, D. L. Burke, J. Carretero, F. J. Castander, L .N. da Costa, M. E. da Silva Pereira, T. M. Davis, J. De Vicente, B. Flaugher, J. Frieman, J. Garcia-Bellido, E. Gaztañaga, G. Gutierrez, S. R. Hinton, D. L. Hollowood, D. J. James, K. Kuehn, O. Lahav, S. Lee, J. L. Marshall, J. Mena-Fernandez, R. Miquel, J. J. Mohr, R. L. C. Ogando, A. A. Plazas Malagon, A. Porredon, S. Samuroff, E. Sanchez, M. Smith, M. Soares-Santos, E. Suchyta, M. E. C. Swanson, D. L. Tucker, V. Vikram, N. Weaverdyck, P. Wiseman, M. Yamamoto   +102 more
doaj   +1 more source