Results 131 to 140 of about 284,450 (301)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Modeling the Mass Distribution and Gravitational Potential of Nearby Disk Galaxies: Implications for the Interstellar Medium Dynamical Equilibrium

The Astrophysical Journal
We characterize stellar, gas, and dark matter mass distributions for 17 nearby massive disk galaxies from the PHANGS sample. This allows us to compute the gravitational potential that vertically confines the interstellar gas and determines its ...
Vivek Vijayakumar, Jiayi Sun, Eve C. Ostriker, Enrico M. Di Teodoro, Konstantin Haubner, Chang-Goo Kim, Adam K. Leroy, Miguel Querejeta   +7 more
doaj   +1 more source

Stellar-Mass Black Holes

Symmetry
Stellar-mass black holes (3 M⊙≲MBH≲150 M⊙) are the natural product of the evolution of heavy stars (Mstar≳20 M⊙). In our Galaxy, we expect that 108–109 stellar-mass black holes have been formed from the gravitational collapse of heavy stars, but currently we know fewer than 100 objects.
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Statistical Predictions of the Accreted Stellar Halos around Milky Way-Like Galaxies

The Open Journal of Astrophysics
In the $Λ$CDM paradigm, stellar halos form through the accretion and disruption of satellite galaxies. We introduce new semi-analytic modeling within the SatGen framework to track the ex-situ stellar components of Milky Way--like galaxies across large ...
J. Sebastian Monzon, Frank C. van den Bosch, Martin P. Rey   +2 more
doaj   +1 more source

Counting Low-Mass Stars in Integrated Light

, 2012
Low-mass stars ...
Conroy, Charlie, van Dokkum, Pieter
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A census of metals and baryons in stars in the local Universe

, 2008
We combine stellar metallicity and stellar mass estimates for a large sample of galaxies drawn from the SDSS DR2 spanning wide ranges in physical properties, in order to derive an inventory of the total mass of metals and baryons locked up in stars today.
Abazajian, Abraham, Allende Prieto, Anna Gallazzi, Asplund, Asplund, Baldry, Baldry, Baugh, Bell, Bell, Bell, Bernardi, Bertone, Blanton, Borch, Bouché, Bouché, Bresolin, Brinchmann, Brinchmann, Bruzual, Bundy, Calura, Chabrier, Cid Fernandes, Cole, Cole, Colless, Connolly, Conti, Cowie, Croton, Davis, Davé, De Lucia, De Lucia, De Lucia, Dickinson, Dickinson, Driver, Driver, Dunne, Edmunds, Ellison, Erb, Ferrara, Fukugita, Fukugita, Gallazzi, Gallazzi, Glazebrook, Glazebrook, Heavens, Heavens, Henry, Hernquist, Hopkins, Ivison, Jarle Brinchmann, Jimenez, Juneau, Kauffmann, Kobayashi, Kobulnicky, Kobulnicky, Kochanek, Korn, Lanzetta, Le Fèvre, Lilly, Lilly, Lilly, MacArthur, Madau, Madau, Madgwick, Mehlert, Monaco, Nagamine, Ocvirk, Pagel, Panter, Pei, Pei, Pettini, Pettini, Pettini, Pettini, Prochaska, Péroux, Péroux, Péroux, Rudnick, Rudnick, Salpeter, Salucci, Schlegel, Shankar, Shapley, Simon D. M. White, Springel, Steidel, Steidel, Strateva, Stéphane Charlot, Thomas, Thomas, Tojeiro, Tremonti, Vanzella, York, Zheng, Zheng   +113 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source