Results 191 to 200 of about 3,828,801 (363)

Intense Star Cluster Formation: Stellar Masses, the Mass Function, and the Fundamental Mass Scale

open access: yesThe Astrophysical Journal Letters
Within the birth environment of a massive globular cluster, the combination of a luminous young stellar population and a high column density induces a state in which the thermal optical depth and radiation pressure are both appreciable.
Christopher D. Matzner
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

Star−Disk Collisions: Implications for Quasi-periodic Eruptions and Other Transients near Supermassive Black Holes

open access: yesThe Astrophysical Journal
We use Athena++ to study the hydrodynamics of repeated star−accretion disk collisions close to supermassive black holes, and we discuss their implications for the origin of quasi-periodic eruptions (QPEs) and other repeating nuclear transients.
Philippe Z. Yao   +4 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Scalable hierarchical BayeSN inference: Investigating dependence of SN Ia host galaxy dust properties on stellar mass and redshift [PDF]

open access: green
Matthew Grayling   +7 more
openalex   +1 more source

Stellar-mass Black Holes in Globular Clusters: Dynamical consequences and observational signatures [PDF]

open access: green, 2019
Abbas Askar   +5 more
openalex   +1 more source

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