Results 191 to 200 of about 111,751 (340)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Systematic variation of the stellar initial mass function with velocity dispersion in early-type galaxies [PDF]

, 2012
Ignacio Ferreras, F. La Barbera, I. G. de la Rosa, A. Vazdekis, R. R. de Carvalho, J. Falcón‐Barroso, E. Ricciardelli   +6 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

First constraints on the stellar mass function of star-forming clumps at the peak of cosmic star formation

, 2018
M. Dessauges‐Zavadsky, Angela Adamo
openalex   +1 more source

THE VMC SURVEY. XVIII. RADIAL DEPENDENCE OF THE LOW-MASS, 0.55–0.82M_⊙STELLAR MASS FUNCTION IN THE GALACTIC GLOBULAR CLUSTER 47 TUCANAE [PDF]

, 2015
Chaoli Zhang, Chengyuan Li, Richard de Grijs, Kenji Bekki, Licai Deng, S. Zaggia, Stefano Rubele, Andrés E. Piatti, Maria-Rosa L. Cioni, Jim Emerson, Bi‐Qing For, V. Ripepi, M. Marconi, V. D. Ivanov, Li Chen   +14 more
openalex   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Erratum: “Retired A Stars Revisited: An Updated Giant Planet Occurrence Rate as a Function of Stellar Metallicity and Mass” (2018, ApJ, 860, 109) [PDF]

, 2019
Luan Ghezzi, Benjamin T. Montet, John Asher Johnson   +2 more
openalex   +1 more source

Universal Upper End of the Stellar Initial Mass Function in the Young and Compact LEGUS Clusters [PDF]

, 2023
DooSeok Jung, Daniela Calzetti, Matteo Messa, M. H. Heyer, Mattia Sirressi, Sean T. Linden, Angela Adamo, Rupali Chandar, M. Cignoni, D. Cook, Clare L. Dobbs, Bruce G. Elmegreen, A. Evans, Michele Fumagalli, J. S. Gallagher, Deidre A. Hunter, Kelsey E. Johnson, Robert C. Kennicutt, Mark R. Krumholz, D. Schaerer, Elena Sabbi, L. J. Smith, M. Tosi, Aida Wofford   +23 more
openalex   +1 more source