Results 101 to 110 of about 143,610 (241)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Constraints on the relationship between stellar mass and halo mass at low and high redshift

, 2009
We use a statistical approach to determine the relationship between the stellar masses of galaxies and the masses of the dark matter halos in which they reside.
Andrea V. Macciò, Bell, Benjamin P. Moster, Berlind, Bertschinger, Brown, Bryan, Christian Maulbetsch, Cole, Conroy, Conroy, Drory, Drory, Fall, Frank C. van den Bosch, Kauffmann, Klypin, Kravtsov, Lin, Lin, Ludwig Oser, Marín, Moster, Press, Rachel S. Somerville, Shankar, Spergel, Tasitsiomi, Thorsten Naab, Tinker, White, White, Yan, Yang, Yang, Zehavi, Zehavi, Zehavi, Zheng   +38 more
core   +1 more source

AME - Asteroseismology Made Easy. Estimating stellar properties by use of scaled models [PDF]

, 2014
We present a new method to obtain stellar properties for stars exhibiting solar-like oscillations in an easy, fast, and transparent way. The method, called Asteroseismology Made Easy (AME), can determine stellar masses, mean-densities, radii, and surface
Aguirre, V. Silva, Kjeldsen, H., Lundkvist, M.   +2 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

EIGER. V. Characterizing the Host Galaxies of Luminous Quasars at z ≳ 6

The Astrophysical Journal
We report JWST/NIRCam measurements of quasar host galaxy emissions and supermassive black hole (SMBH) masses for six quasars at 5.9 < z < 7.1 in the Emission-line galaxies and Intergalactic Gas in the Epoch of Reionization (EIGER) project. We obtain deep
Minghao Yue, Anna-Christina Eilers, Robert A. Simcoe, Ruari Mackenzie, Jorryt Matthee, Daichi Kashino, Rongmon Bordoloi, Simon J. Lilly, Rohan P. Naidu   +8 more
doaj   +1 more source

Star Formation Rates and Metallicities of K-selected Star Forming Galaxies at z~2 [PDF]

, 2008
We present spectroscopy of 15 star-forming BzK galaxies (sBzKs) with K(AB)
Alonso-Herrero, Blanc, Bolzonella, Brooks, Calzetti, Chun Ly, Colbert, Daddi, Daddi, Dannerbauer, Dickinson, Erb, Erb, Erb, Fontana, Hayashi, Hicks, Ichikawa, Kajisawa, Kashikawa, Kazuhiro Shimasaku, Kentaro Motohara, Kewley, Kobulnicky, Kong, Kriek, Lane, Liu, Ly, Makiko Yoshida, Masao Hayashi, Masato Onodera, Matthew A. Malkan, Nobunari Kashikawa, Peng, Press, Reddy, Reddy, Richards, Sadanori Okamura, Savaglio, Sawicki, Tremonti, Yuka Katsuno Uchimoto   +43 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Optical and radio properties of extragalactic radio sources with recurrent jet activity

, 2017
We present a sample of 74 radio sources with recurrent jet activity. The sample consists of 67 galaxies, 2 quasars and 5 unidentified sources, selected from the published data or are newly recognized.
Jamrozy, M., Kozieł-Wierzbowska, D., Kuźmicz, A., Weżgowiec, M.   +3 more
core   +1 more source

Stellar Masses and Radii as Constraints on Stellar Models [PDF]

International Astronomical Union Colloquium, 1993
AbstractThe current status of empirical data on stellar masses and radii of sufficient accuracy to give constraints on stellar models is reviewed. Results from the best-studied eclipsing binaries can already trace the main-sequence evolution of 1-10 M⊙ stars in considerable detail and will be even more useful when supplemented by chemical abundance ...
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source