Results 121 to 130 of about 18,267 (299)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Astrophysical JournalThe presence of strong correlations between supermassive black hole (SMBH) masses and galaxy properties like stellar mass have been well established for the local Universe, but how these scaling relations evolve with cosmic time is yet to be settled in ...
Matías Bravo +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 1997 15 pages incl. 4 figures (LaTeX, style files included); The figures are larger than in the 12 page review that is to appear in PASPC: Brown Dwarfs and Extrasolar Planets, R. Rebolo, M.R. Zapatero Osorio and E.
openaire +2 more sources
, 2017 Galaxy starlight at 3.6 μm is an excellent tracer of stellar mass. Here we use the latest 3.6 μm imaging from the Spitzer Space Telescope to measure the total stellar mass and effective radii in a homogeneous way for a sample of galaxies from the SAGES ...
Luciana Sinpetru (19016540) +5 more
core +2 more sources
The Astrophysical JournalThe outshining light from active galactic nuclei (AGNs) poses significant challenges in studying the properties of AGN host galaxies. To address this issue, we propose a novel approach that combines image decomposition and spectral energy distribution ...
Haoran Yu +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The NEID Earth Twin Survey. II. Dynamical Masses in Seven High-acceleration Star Systems [PDF]
We present a set of companion dynamical masses and orbital parameters of seven star systems from the NEID Earth Twin Survey with significant absolute astrometric accelerations between the epochs of Hipparcos and Gaia.
Wang, Sharon X. +28 more
core +1 more source
Stellar Masses and Star Formation Rates of Lensed, Dusty, Star-forming Galaxies from the SPT Survey [PDF]
, 2015 To understand cosmic mass assembly in the universe at early epochs, we primarily rely on measurements of the stellar masses and star formation rates (SFRs) of distant galaxies. In this paper, we present stellar masses and SFRs of six high-redshift (2.8 ≤
Weiss, A +41 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source