Results 141 to 150 of about 716,854 (348)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Evolution of the Most Massive Galaxies to z=0.6: I. A New Method for Physical Parameter Estimation

, 2011
We use principal component analysis (PCA) to estimate stellar masses, mean stellar ages, star formation histories (SFHs), dust extinctions and stellar velocity dispersions for ~290,000 galaxies with stellar masses greater than $10^{11}Msun and redshifts ...
Abazajian, Abazajian, Adam S. Bolton, Aihara, Alongi, Asari, Balogh, Bell, Bell, Bell, Benjamin A. Weaver, Benson, Bernardi, Best, Best, Best, Blanton, Boehringer, Borch, Bower, Bressan, Brinchmann, Bruzual, Budavári, Cappellari, Chabrier, Charlot, Chen, Chen, Christy A. Tremonti, Claudia Maraston, Conroy, Croton, Donald P. Schneider, Drory, Eisenstein, Eminian, Fabian, Fagotto, Fagotto, Fukugita, Gallazzi, Gallazzi, Gallazzi, Girardi, Gorgas, Graham, Graham, Graham, Guinevere Kauffmann, Gunawardhana, Gunn, Gunn, Heavens, Heckman, Hogg, Hoversten, Hu, John Chisholm, Jon Brinkmann, Juneau, Kang, Kannappan, Karim, Katarina Kovač, Kauffmann, Kauffmann, Kauffmann, Kauffmann, Kauffmann, Kaviraj, Kaviraj, Kennicutt, Kevin Bundy, Kriek, Kriek, Kroupa, Le Borgne, Li, Li, Lu, Madgwick, Madgwick, Maraston, Maraston, Maraston, Maraston, Masters, McNamara, Meynet, Naab, Oconnell, Padmanabhan, Panter, Pearce, Pier, Salim, Salim, Salpeter, Scarlata, Schaller, Schlegel, Schlegel, Simon White, Stoughton, Strauss, Sánchez-Blázquez, Thomas, Thomas, Thomas, Timothy M. Heckman, Tremaine, Tremonti, van der Wel, Vazdekis, Wang, Wang, Wild, Worthey, Worthey, Yan-Mei Chen, York, Zheng, Zibetti   +123 more
core   +1 more source

Stars in the age of micro-arc-second astrometry [PDF]

, 2007
The understanding and modeling of the structure and evolution of stars is based on statistical physics as well as on hydrodynamics. Today, a precise identification and proper description of the physical processes at work in stellar interiors are still ...
Alecian, Alecian, Bedding, Christensen-Dalsgaard, Cordier, Grevesse, Grevesse, Gustafsson, Lebreton, Mathis, Mazumdar, Miglio, Montalbán, Perryman, Piau, Richard, Roxburgh, Y. Lebreton   +17 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Evolution and Nucleosynthesis of Very Massive Stars

, 2014
In this chapter, after a brief introduction and overview of stellar evolution, we discuss the evolution and nucleosynthesis of very massive stars (VMS: M>100 solar masses) in the context of recent stellar evolution model calculations. This chapter covers
A. Burrows, A. Chieffi, A. Chieffi, A. Heger, A. Heger, A. Maeder, A. Maeder, A. Maeder, A. Maeder, A. Maeder, A. Maeder, A. Maeder, A. Maeder, A. Maeder, A. Sander, A. Stacy, A. T. Potter, B. Chaboyer, B. Paxton, C. D. Ott, C. Georgy, C. Georgy, C. Georgy, C. Jager de, C. Jager de, C. L. Fryer, D. F. Figer, E. Chatzopoulos, E. E. Salpeter, E. Knobloch, E. O’Connor, F. R. N. Schneider, G. Gräfener, G. Meynet, G. Meynet, G. Meynet, H. C. Spruit, H. Umeda, H. Zeipel von, J. Braithwaite, J. C. Wheeler, J. J. Eldridge, J. J. Eldridge, J. Krtička, J. R. Bond, J. S. Vink, J. T. Loon van, J. Zahn, J.-P. Zahn, K. Fricke, L. Dessart, L. Dessart, L. E. Muijres, M. Brüggen, M. E. Bennett, M. S. Oey, N. Christlieb, N. Langer, N. Yusof, P. A. Crowther, P. Eggenberger, P. Goldreich, R. Hirschi, R. Hirschi, R. Hirschi, R. Hirschi, R. Hirschi, R. J. Sylvester, R. Kippenhahn, R. Kippenhahn, R. Walder, S. E. Woosley, S. E. Woosley, S. Ekström, S. Ekström, S.-C. Yoon, S.-C. Yoon, S.-C. Yoon, T. Abel, T. H. Greif, T. Yoshida, U. Frischknecht, V. Bromm, V. M. Canuto, W.-R. Hamann   +84 more
core   +1 more source

Star Formation Rates and Metallicities of K-selected Star Forming Galaxies at z~2 [PDF]

, 2008
We present spectroscopy of 15 star-forming BzK galaxies (sBzKs) with K(AB)
Alonso-Herrero, Blanc, Bolzonella, Brooks, Calzetti, Chun Ly, Colbert, Daddi, Daddi, Dannerbauer, Dickinson, Erb, Erb, Erb, Fontana, Hayashi, Hicks, Ichikawa, Kajisawa, Kashikawa, Kazuhiro Shimasaku, Kentaro Motohara, Kewley, Kobulnicky, Kong, Kriek, Lane, Liu, Ly, Makiko Yoshida, Masao Hayashi, Masato Onodera, Matthew A. Malkan, Nobunari Kashikawa, Peng, Press, Reddy, Reddy, Richards, Sadanori Okamura, Savaglio, Sawicki, Tremonti, Yuka Katsuno Uchimoto   +43 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Optical and radio properties of extragalactic radio sources with recurrent jet activity

, 2017
We present a sample of 74 radio sources with recurrent jet activity. The sample consists of 67 galaxies, 2 quasars and 5 unidentified sources, selected from the published data or are newly recognized.
Jamrozy, M., Kozieł-Wierzbowska, D., Kuźmicz, A., Weżgowiec, M.   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source