Results 111 to 120 of about 18,267 (299)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The energy budget of stellar magnetic fields [PDF]

, 2015
VS acknowledges the support of an Science & Technology Facilities Council (STFC) studentship. AAV acknowledges support from the Swiss National Science Foundation through an Ambizione Fellowship.
Fares, R.,, Gregory, S. G.; id_orcid, Rosén, L., Waite, I. A.,, Rosén, Lisa, Bouvier, J.,, Petit, P., Jeffers, Sandra Victoria, do Nascimento, J. D., Jr.,, Nascimento, J. D., Do, Rosén, Lisa,, See, Wyke Chun Victor, Marsden, S. C., See, V., Donati, J. F., Morin, J., Jardine, Moira Mary, Fares, R., Hussain, G. A. J., Petit, P.,, Moutou, C., Saikia, S. Boro, Donati, J.-F., Hussain, Gaitee Ara Jaffer, Hussain, G.,, Morin, J.,, do Nascimento, Jose-Dias Jr., Vidotto, Aline, Jeffers, S. V., Folsom, C. P.,, Nascimento, J. D.,, Moutou, C.,, Folsom, C. P., do Nascimento, J. D., Jr., Vidotto, A. A.,, Gregory, S. G., do Nascimento, J. D., Hussain, G., Donati, J. -F., Jardine, M., Vidotto, A. A., Jardine, M.,, Boro Saikia, S., Nascimento Júnior, José Dias do, Marsden, S. C.,, Saikia, S. Boro,, Gregory, Scott, See, V.,, Bouvier, J., Waite, I. A., Jeffers, Sandra V., Waite, A., Morin, Julien, Fares, Rim, Donati, J. -F, do Nascimento Jr., J. D., Jeffers, S.V.   +56 more
core   +1 more source

The Baryonic Tully–Fisher Relation. II. Stellar Mass Models

The Astronomical Journal
We present new color–ϒ _* (mass-to-light ratio) models to convert Wide-field Infrared Survey Explorer W1 fluxes into stellar masses. We outline a range of possible star formation histories and chemical evolution scenarios to explore the confidence limits
Francis Duey, James Schombert, Stacy McGaugh, Federico Lelli   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Magnetospheric accretion and pre-main-sequence stellar masses

, 1998
We present a method of determining lower limits on the masses of pre-main-sequence (PMS) stars and so constraining the PMS evolutionary tracks. This method uses the redshifted absorption feature observed in some emission-line profiles of T Tauri stars ...
Meyer, Michael R, Folha, Daniel FM, Bonnell, Ian Alexander, Emerson, James P, Smith, Kester W, Tout, Christopher A   +5 more
core  

The stellar masses and specific star-formation rates of submillimetre galaxies

, 2012
Establishing the stellar masses, and hence specific star-formation rates of submillimetre galaxies is crucial for determining the role of such objects in the cosmic history of galaxy/star formation.
M. J. Michałowski, J. S. Dunlop, C. C. Hayward, D. Watson, Hayward, C.C., Hjorth, Jens, J. Hjorth, Dunlop, J.S., Cirasuolo, M., Watson, Darach Jafar, M. Cirasuolo, Michalowski, M.J.   +11 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The stellar ‘Snake’ – II. The mass function

Monthly Notices of the Royal Astronomical Society
ABSTRACT We present a comprehensive investigation on the mass function (MF) of a snake-like stellar structure in the solar neighbourhood, building on our previous discovery. To ensure the reliability of the data, we reselect the member stars of the Stellar ‘Snake’ in the latest Gaia Data Release 3 using the same approach as the initial ...
Xiang-Ming Yang, Sarah A Bird, Jiadong Li, Hai-Jun Tian, Dan Qiu, Jia-Peng Li, Cheng-Yuan Li, Gao-Chao Liu, Peng Zhang, Ju-Yong Zhang, Zhi-Ping Chen   +10 more
openaire   +2 more sources

Component masses in stellar and sub-stellar binaries from Gaia astrometry and photometry

Astronomy & Astrophysics
The masses of stars and planets can be measured dynamically in binary systems. For an unresolved binary, time series astrometry reveals the orbital parameters, but it cannot provide the component masses, because we observe only the motion of the system's
Bailer-Jones C. A. L., Kreidberg L.
doaj   +1 more source