Results 111 to 120 of about 143,610 (241)

The Galaxy–Active Galactic Nucleus Scaling Relations over 13 Billion Years in SHARK v2.0. I. Supermassive Black Hole Masses

The Astrophysical Journal
The presence of strong correlations between supermassive black hole (SMBH) masses and galaxy properties like stellar mass have been well established for the local Universe, but how these scaling relations evolve with cosmic time is yet to be settled in ...
Matías Bravo, Claudia del P. Lagos, Katy L. Proctor, Ángel Chandro-Gómez, Chris Power   +4 more
doaj   +1 more source

Weighing the young stellar discs around Sgr A*

, 2005
It is believed that young massive stars orbiting Sgr A* in two stellar discs on scales of 0.1-0.2 parsecs were formed either farther out in the Galaxy and then quickly migrated inward, or in situ in a massive self-gravitating disc.
Cuadra, Jorge, Dehnen, Walter, Genzel, Reinhard, Nayakshin, Sergei   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A New Approach to Constraining Properties of Active Galactic Nucleus Host Galaxies by Combining Image and Spectral Energy Distribution Decomposition: Testing upon the MBH–M⋆ Relation

The Astrophysical Journal
The outshining light from active galactic nuclei (AGNs) poses significant challenges in studying the properties of AGN host galaxies. To address this issue, we propose a novel approach that combines image decomposition and spectral energy distribution ...
Haoran Yu, Lulu Fan, Yunkun Han, Weibin Sun, Yihang Zhang, Xuheng Ding, Yongquan Xue   +6 more
doaj   +1 more source

The Galaxy Population of Abell 1367: The Stellar Mass-Metallicity Relation

, 2011
Using wide baseline broad-band photometry, we analyse the stellar population properties of a sample of 72 galaxies, spanning a wide range of stellar masses and morphological types, in the nearby spiral-rich and dynamically young galaxy cluster Abell 1367.
Balogh, Barnes, Barnes, Bell, Boselli, Bressan, Burstein, Buta, Butcher, Carter, Cortese, De Lucia, de Vaucouleurs, Donnelly, Dressler, Dressler, Driver, Faber, Gallazzi, Gao, Gavazzi, Gavazzi, Godwin, Gratton, Grebenev, Guenther, Guzmán, Hempel, James, Katz, Kennicutt, Kewley, Kewley, Korn, Kroupa, Lane, Lee, Lewis, M. Mouhcine, MacArthur, Michel-Dansac, Mihos, Moss, Moss, Moss, Moss, Nelan, Odell, P. A. James, Peeples, Peletier, Peletier, Pietrinferni, Poggianti, Puzia, Rakos, Rakos, Rakos, Rakos, Rose, Rose, Rupke, Rupke, Sakai, Schiavon, Schlegel, Schombert, Schombert, Smail, Smith, Smith, Struble, Sun, Sánchez-Blázquez, Taylor, Terlevich, Terlevich, Thomas, Thomas, Vazdekis, W. Kriwattanawong, West, Worthey, Worthey, Zaritsky   +84 more
core   +1 more source

An Improved Method for Estimating the Masses of Stars with Transiting Planets [PDF]

, 2010
To determine the physical parameters of a transiting planet and its host star from photometric and spectroscopic analysis, it is essential to independently measure the stellar mass. This is often achieved by the use of evolutionary tracks and isochrones,
A. Collier Cameron, B. Enoch, Bakos, Cameron, Charbonneau, Christian, Claret, Collier Cameron, Fernandez, Gillon, Hebb, Hebb, Hellier, Hellier, Johnson, Joshi, L. Hebb, Lister, Mandel, N. R. Parley, Pollacco, Seager, Shporer, Skillen, Smith, Southworth, Southworth, Sozzetti, Sozzetti, Stempels, Torres, West, West, Wilson, Winn   +34 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Constraints for the Progenitor Masses of Historic Core-Collapse Supernovae

, 2018
We age-date the stellar populations associated with 12 historic nearby core-collapse supernovae (CCSNe) and 2 supernova impostors, and from these ages, we infer their initial masses and associated uncertainties.
Dalcanton, Julianne J., Dolphin, Andrew E., Gilbert, Karoline, Hillis, Tristan J., Murphy, Jeremiah W., Williams, Benjamin F.   +5 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source