Results 161 to 170 of about 974 (262)

False positives in gravitational wave campaigns: the electromagnetic perspective. [PDF]

Philos Trans A Math Phys Eng Sci
Oates S.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Multi-messenger gravitational lensing. [PDF]

Philos Trans A Math Phys Eng Sci
Smith GP, Baker T, Birrer S, Collins CE, Ezquiaga JM, Goyal S, Hannuksela OA, Hemanta P, Hendry MA, Janquart J, Keitel D, Levan AJ, Lo RKL, More A, Nicholl M, Pastor-Marazuela I, Ponte Pérez AI, Ubach H, Uronen LE, Wright M, Zumalacarregui M, Bianco F, Çalişkan M, Chan JCL, Colangeli E, Gompertz BP, Haines CP, Hayes EE, Hu B, Lamb GP, Liu A, Mandhai S, Narola H, Nguyen QL, Poon JSC, Ryczanowski D, Seo E, Shajib AJ, Shan X, Tanvir N, Vujeva L.   +40 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A binary-related origin mediated by environmental conditions for blue straggler stars. [PDF]

Nat Commun
Ferraro FR, Lanzoni B, Vesperini E, Dalessandro E, Cadelano M, Pallanca C, Beccari G, Nardiello D, Libralato M, Piotto G.   +9 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Characterization of candidate stellar merger progenitors

Stellar mergers have traditionally been detected because of their outbursts. A study by Addison et al.(2022) proposed a method to select them based on their position in the Hertzsprung Gap and an increase in luminosity, although without extinction values, resulting in 21 progenitor candidates for Luminous Red Novae.
openaire   +1 more source

Potential impact of the Sagittarius dwarf galaxy on the formation of young O-rich stars. [PDF]

Nat Commun
Sun T, Bi S, Chen X, Chen Y, Lu YL, Liu C, Buck T, Zhang X, Li T, Li Y, Wu Y, Ge Z, Ye L.   +12 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The emergence of globular clusters and globular-cluster-like dwarfs. [PDF]

Nature
Taylor ED, Read JI, Orkney MDA, Kim SY, Pontzen A, Agertz O, Rey MP, Andersson EP, Collins MLM, Yates RM.   +9 more
europepmc   +1 more source