Results 171 to 180 of about 46,211 (288)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Black Holes as Laboratories: Tests of General Relativity. [PDF]

Gen Relativ Gravit
Gregory R, Nissanke S.
europepmc   +1 more source

Stellar mergers in the era of large surveys

, 2019
Most stars in our Universe live in binaries. Unstable mass transfer from one star to another can lead to the formation of a common envelope: a shared gaseous shell where both stars orbit. The end of this phase is marked by the quick spiral-in of the secondary star towards its companion, leading to violent interactions between the components. The whole,
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Lone black holes promise fresh insights into the fates of massive stars. [PDF]

Proc Natl Acad Sci U S A
Croswell K.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Formation time-scales for stellar bars in diverse galactic discs. [PDF]

Mon Not R Astron Soc
Frosst M, Obreschkow D, Ludlow A.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Evidence of star cluster migration and merger in dwarf galaxies. [PDF]

Nature
Poulain M, Smith R, Duc PA, Marleau FR, Habas R, Durrell PR, Fensch J, Lim S, Müller O, Paudel S, Sánchez-Janssen R.   +10 more
europepmc   +1 more source

Characterization of candidate stellar merger progenitors

Stellar mergers have traditionally been detected because of their outbursts. A study by Addison et al.(2022) proposed a method to select them based on their position in the Hertzsprung Gap and an increase in luminosity, although without extinction values, resulting in 21 progenitor candidates for Luminous Red Novae.
openaire   +1 more source