Results 151 to 160 of about 3,339,915 (332)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ASTA -- Theoretical Stellar Astrophysics and Asteroseismology [PDF]
, 2017 Theoretical Stellar Physics and ...
Godart, Mélanie
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Microlensing and the physics of stellar atmospheres
, 2001 The simple physics of microlensing provides a well understood tool with which to probe the atmospheres of distant stars in the Galaxy and Local Group with high magnification and resolution.
Sackett, PD
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Stellar-mass black holes (3 M⊙≲MBH≲150 M⊙) are the natural product of the evolution of heavy stars (Mstar≳20 M⊙). In our Galaxy, we expect that 108–109 stellar-mass black holes have been formed from the
Cosimo Bambi
core +1 more source
Potamides: Mapping Dark Matter Halo Shapes from Stellar Stream Tracks in the Local Universe
The Astrophysical JournalStellar streams trace the gravitational potential of their host galaxies and offer a direct probe of dark matter halo geometry. Cosmological simulations predict that halo shapes depend on both baryonic physics and the nature of dark matter, yet ...
Sirui Wu +5 more
doaj +1 more source
PhysFormer: A physics-embedded model for physically consistent stellar spectral synthesis
Astronomy & AstrophysicsContext. High-resolution theoretical stellar spectral modeling provides essential support for the analysis and interpretation of observed spectra, underpinning studies of stellar atmospheric physics and the processing of large-scale spectroscopic surveys.
Wang Siqi +8 more
doaj +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source