Results 141 to 150 of about 3,339,915 (332)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
, 2009 Stellar coronae, defined by the ensemble of magnetic field structures above stellar photospheres and chromospheres together with their thermal or non-thermal plasma content, play an important role in our understanding of stellar magnetic fields, the stellar magnetic dynamo, and interactions between a star and its environment.
openaire +2 more sources
Problems and prospects in stellar physics [PDF]
, 2008 peer reviewedMain difficulties and uncertainties in stellar physics originate in the modelling of convection, microscopic and macroscopic transport mechanisms and rotation.
Dupret, Marc-Antoine
core +1 more source
An Expanded Set of Los Alamos OPLIB Tables in MESA: Type-1 Rosseland-mean Opacities and Solar Models
The Astrophysical JournalWe present a set of 1194 Type-1 Rosseland-mean opacity tables for four different metallicity mixtures. These new Los Alamos OPLIB atomic radiative opacity tables are an order of magnitude larger in number than any previous opacity table release, and span
Ebraheem Farag +13 more
doaj +1 more source
Spectropolarimetry for Discerning Geometry and Structure in Circumstellar Media of Hot Massive Stars
GalaxiesSpectropolarimetric techniques are a mainstay of astrophysical inquiry, ranging from Solar System objects to the Cosmic Background Radiation. This review highlights applications of stellar polarimetry for massive hot stars, particularly in the context of
Richard Ignace +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Physical processes in stellar evolution [PDF]
, 2008 We firstly examine the possible roles of mass loss and mixing as a function of stellar masses. Then we review the present observational status about additional mixing processes in massive stars. Various evidences from main-sequence OB stars, from blue supergiants, from SN 1987A and from Wolf-Rayet stars are given in favour of a significant mixing in ...
openaire +1 more source