Results 131 to 140 of about 6,039,312 (259)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The Effects of Accretion Feedback on Stellar Evolution in AGN Disks
The Astrophysical JournalStars embedded in the accretion disks of active galactic nuclei (AGN) can accrete rapidly from their surroundings, dramatically altering their structure and evolution.
Alexander J. Dittmann, Matteo Cantiello
doaj +1 more source
Mechanical heating in stellar chromospheres using the sun as a test case [PDF]
, 1973 The shock dissipation hypothesis for solar atmospheric heating is extended to stellar chromospheres of late type stars which have significant convective envelopes. Principle wave modes are studied for their generation, propagation, and heating properties
Jordan, S. D.
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Astrophysical JournalThe outshining light from active galactic nuclei (AGNs) poses significant challenges in studying the properties of AGN host galaxies. To address this issue, we propose a novel approach that combines image decomposition and spectral energy distribution ...
Haoran Yu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Variable Stars in M31 Stellar Clusters from the Panchromatic Hubble Andromeda Treasury
The Astrophysical JournalVariable stars in stellar clusters can offer key constraints on stellar evolution and pulsation models, utilizing estimates of host cluster properties to constrain stellar physical parameters.
Richard Smith +11 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source