Results 131 to 140 of about 220,237 (344)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Confusing Binaries: The Role of Stellar Binaries in Biasing Disk Properties in the Galactic Center [PDF]

, 2018
Smadar Naoz, A. M. Ghez, Aurélien Hees, Tuan Do, Gunther Witzel, Jessica R. Lu   +5 more
openalex   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The California-Kepler Survey. XI. A Survey of Chromospheric Activity through the Lens of Precise Stellar Properties

The Astrophysical Journal
Surveys of exoplanet host stars are valuable tools for assessing population level trends in exoplanets, and their outputs can include stellar ages, activity, and rotation periods.
Howard Isaacson, Stephen R. Kane, Brad Carter, Andrew W. Howard, Lauren Weiss, Erik A. Petigura, Benjamin Fulton   +6 more
doaj   +1 more source

The Initial Mass Function and Other Stellar Properties Across the Core of the Hydra I Cluster [PDF]

, 2023
I. Lonoce, Wendy L. Freedman, A. Feldmeier   +2 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Spectroscopic Distance, Mass, and Age Estimations for APOGEE DR17

The Astronomical Journal
We derive distances and masses of stars from the Sloan Digital Sky Survey (SDSS) Apache Point Observatory Galactic Evolution Experiment Data Release 17 using simple neural networks.
Alexander Stone-Martinez, Jon A. Holtzman, Julie Imig, Christian Nitschelm, Keivan G. Stassun, Joel R. Brownstein   +5 more
doaj   +1 more source

The SAGA so far: reading the history of the Galaxy with asteroseismology

EPJ Web of Conferences, 2015
Asteroseismology has the capability of delivering stellar properties which would otherwise be inaccessible, such as radii, masses and thus ages of stars.
Casagrande Luca, Aguirre Victor Silva, Serenelli Aldo M., Stello Dennis, Feltzing Sofia, Schlesinger Katharine J.   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Asteroseismic Calibration of the Rossby Number and Its Connection to the Stellar Dynamo and Fundamental Properties

The Astrophysical Journal
The stellar Rossby number, a dimensionless parameter quantifying the influence of Coriolis forces on convective motions, plays a pivotal role in understanding magnetic stellar evolution.
Alfio M. Bonanno, Enrico Corsaro, Travis S. Metcalfe, Sylvain N. Breton, Orlagh L. Creevey, Christopher J. Lindsay   +5 more
doaj   +1 more source