Results 141 to 150 of about 220,237 (344)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Early-type Galaxies on the Star Formation Main Sequence: Internal Star Formation Geometries Revealed with MaNGA and Their Environmental Origin

The Astrophysical Journal
Star-forming galaxies on the main sequence (MS) are often regarded as a uniform population characterized by similar global star formation properties. However, there exists a diversity in galaxy morphologies at a fixed stellar mass and star formation rate.
Shuhei Koyama, Yusei Koyama, Takuji Yamashita, Masahiro Konishi, Kosuke Kushibiki, Kentaro Motohara   +5 more
doaj   +1 more source

Hierarchically modelling Kepler dwarfs and subgiants to improve inference of stellar properties with asteroseismology [PDF]

, 2021
Alexander J Lyttle, G. R. Davies, Tanda Li, Lindsey Carboneau, Ho-Hin Leung, Harry Westwood, W. J. Chaplin, Oliver J. Hall, Daniel Huber, M. B. Nielsen, Sarbani Basu, R. A. García   +11 more
openalex   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Physical properties and scaling relations of molecular clouds: the effect of stellar feedback [PDF]

, 2018
Kearn Grisdale, Oscar Agertz, Florent Renaud, Alessandro B. Romeo   +3 more
openalex   +1 more source

Kilometer-precise (UII) Umbriel physical properties from the multichord stellar occultation on 2020 September 21 [PDF]

, 2023
M. Assafin, S Santos-Filho, B. E. Morgado, A. R. Gomes-Júnior, B. Sicardy, G. Margoti, G. Benedetti-Rossi, F. Braga-Ribas, T Laidler, J. I. B. Camargo, R. Vieira-Martins, Theodore J. Swift, David Dunham, T. George, J. Bardecker, Craig Anderson, R. Nolthenius, K. Bender, G. R. Viscome, David Oesper, Richard G. Dunford, Kai Getrost, Christopher L. Kitting, K Green, R Bria, Are Olsen, A. Scheck, Brian Billard, Myron E. Wasiuta, R Tatum, P. D. Maley, Dennis di Cicco, Dale M. Gamble, Peter Ceravolo, Debra Ceravolo, W. Hanna, Nathan Smith, N Carlson, Steven F. Messner, Judy A. Bean, John G. Moore, Richard M. Venable   +41 more
openalex   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Updated properties of the old open cluster Melotte 66: Searching for multiple stellar populations [PDF]

, 2014
Giovanni Carraro, Gayandhi de Silva, Lorenzo Monaco, Antonino P. Milone, Renee Mateluna   +4 more
openalex   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Model Choice Matters for Age Inference on the Red Giant Branch

The Astrophysical Journal
Galactic archaeology relies on accurate stellar parameters to reconstruct the Galaxy's history, including information on stellar ages. While the precision of data has improved significantly in recent years, stellar models used for age inference have not ...
Leslie M. Morales, Jamie Tayar, Zachary R. Claytor   +2 more
doaj   +1 more source