Results 161 to 170 of about 220,237 (344)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Properties of stellar images at faint magnitudes [PDF]
, 1980 T. Shanks, S. Phillipps, R. Fong
openalex +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
TESS Asteroseismic Masses and Radii of Red Giants with (and without) Planets
The Astrophysical JournalWe present a study of asteroseismically derived surface gravities, masses, and radii of a sample of red giant stars both with and without confirmed planetary companions using TESS photometric light curves. These red giants were drawn from radial velocity
Myles Pope +3 more
doaj +1 more source
Properties of Black Holes in Stellar Binary Systems
, 2001 Recent X-ray timing and spectral observations of black hole binaries in outburst have redefined methods for investigating the properties of Galactic black holes and the physics of accretion flows. High-frequency X-ray QPOs in 5 systems (60--300 Hz) continue to be investigated as a possible means to constrain black hole mass and spin via interpretation ...
openaire +3 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Cosmic-Ray Propagation in Young Embedded Clusters
The Astrophysical JournalThis paper constructs a quantitative description for the geometrical properties of young stellar clusters using a Delaunay mesh. This approach defines the paths that connect cluster members and can be used to characterize the distribution of path lengths
Marco Fatuzzo, Fred C. Adams
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
The Astrophysical JournalData-driven models for stellar spectra that depend on stellar labels suffer from label systematics which decrease model performance: the stellar labels gap.
Alexander Laroche, Joshua S. Speagle
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source