Results 31 to 40 of about 15,242 (225)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Intense Mass Loss from C-rich AGB Stars at low Metallicity?

, 2008
We argue that the energy injection of pulsations may be of greater importance to the mass-loss rate of AGB stars than metallicity, and that the mass-loss trend with metallicity is not as simple as sometimes assumed.
Andersen, Asplund, Bowen, Feast, Gautschy-Loidl, Groenewegen, Helling, Höfner, Jackson, Jackson, K. Eriksson, L. Mattsson, Lagadec, Matsuura, R. Wahlin, S. Höfner, van Loon, van Loon, Wachter, Wahlin, Westerlund, Winters, Wood   +22 more
core   +1 more source

An Overview of Stellar Pulsation Theory [PDF]

Astrophysics and Space Science, 1993
AbstractIn this paper I will give overview of the stellar pulsation theory. Starting with basic equations I will discuss modal properties of oscillations and excitation mechanisms. I also mention briefly the effects of rotation.
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Pulsational line profile variation of the roAp star HR 3831

, 2005
We report the first comprehensive investigation of the line profile variation caused by non-radial pulsation in a magnetic oscillating chemically peculiar star. Spectrum variation of the well-known roAp star HR 3831 is detected using very high-resolution
Aerts, Baade, Baldry, Baldry, Baldry, Baldry, Balona, Balona, Balona, Bigot, Cunha, Cunha, Dziembowski, Elkin, Hurly, Kanaan, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kupka, Kurtz, Kurtz, Kurtz, Kurtz, Kurtz, Kurtz, Libbrecht, Martinez, Mashonkina, Mathys, Mathys, Matthews, Matthews, Mkrtichian, O. Kochukhov, Piskunov, Polosukhina, Roberts, Ryabchikova, Saio, Saio, Savanov, Schrijvers, Shavrina, Shibahashi, Telting, Telting, Thompson, Watson   +52 more
core   +2 more sources

Pulsational frequency and amplitude modulation in the δ Sct star KIC 7106205 [PDF]

, 2014
Analysis of the Kepler δ Sct star KIC 7106205 showed amplitude modulation in a single pressure mode, whilst all other pressure and gravity modes remained stable in amplitude and phase over the 1470 d length of the data set.
Bowman, Dominic, Kurtz, Donald Wayne
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Automated Nonlinear Stellar Pulsation Calculations: Applications to RR Lyrae stars. The Slope of the Fundamental Blue Edge and the First RRd Model Survey

, 2004
We describe a methodology that allows us to follow the pulsational behavior of an RR Lyrae model consistently and automatically along its evolutionary track throughout the whole instability strip. It is based on the powerful amplitude equation formalism,
Alibert, Beaulieu, Bono, Bono, Bono, Bragaglia, Buchler, Buchler, Buchler, Buchler, Buchler, Castellani, Catelan, Clement, Clementini, Cseresnjes, Demarque, Dorfi, Dorman, Feuchtinger, Gallart, Girardi, Gábor, J. R. Buchler, Jurcsik, Jurcsik, Kolláth, Kolláth, Kolláth, Kolláth, Kovács, Kovács, Kovács, Kovács, Kovács, Lee, Mizerski, Popielski, R. Szabó, Schaller, Soszynski, Soszynski, Szabó, Udalski, van Albada, Walker, Yecko, Z. Kolláth   +47 more
core   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Blue large-amplitude pulsators as a new class of variable stars

, 2017
Regular intrinsic brightness variations observed in many stars are caused by pulsations. These pulsations provide information on the global and structural parameters of the star.
Angeloni, R., di Mille, F., Dziembowski, W. A., Kozlowski, S., Latour, M., Mroz, P., Pawlak, M., Pietrukowicz, P., Poleski, R., Skowron, D., Skowron, J., Soszynski, I., Szymanski, M. K., Udalski, A., Ulaczyk, K., Wyrzykowski, L.   +15 more
core   +2 more sources