Results 41 to 50 of about 481 (259)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
On the Hydrodynamics of Stellar Pulsation and Stability [PDF]
International Astronomical Union Colloquium, 2002 AbstractMuch of our knowledge of the hydrodynamics of stellar oscillations is summarized in the now-classical article by Ledoux & Walraven in volume 51 of the Handbuch der Physik. It is from that article that I, and many others, first learned the subject.
D.O. Gough, Paul Ledoux
openaire +1 more source
CORALIE radial-velocity search for companions around evolved stars (CASCADES)
Astronomy & AstrophysicsAims. We extend the planetary census around massive stellar hosts through a long-term campaign of high-precision radial velocity (RV) measurements on evolved stars. Methods.
Figueira P. +11 more
doaj +1 more source
First Detection of Radio Emission Associated with a Classical Cepheid
The Astronomical Journal, 2023 We report the detection of 15 GHz radio continuum emission associated with the classical Cepheid variable star δ Cephei ( δ Cep) based on observations with the Karl G. Jansky Very Large Array.
L. D. Matthews, N. R. Evans, M. P. Rupen
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Seismological insights into solar and stellar magnetic activity cycles
EPJ Web of Conferences, 2017 The Sun’s magnetic activity cycle varies primarily on a time scale of approximately 11yrs from minimum to maximum and back again. It is well-known that the properties of the Sun’s acoustic oscillations are affected by the near-surface internal magnetic ...
Broomhall Anne-Marie
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Constraints on Stellar Evolution from Pulsations [PDF]
Symposium - International Astronomical Union, 1984 Consideration of the many types of intrinsic variable stars, that is, those that pulsate, reveals that perhaps a dozen classes can indicate some constraints that affect the results of stellar evolution calculations, or some interpretations of observations. Many of these constraints are not very strong or may not even be well defined yet. In this review
openaire +2 more sources
Energetic properties of stellar pulsations across the Hertzsprung-Russell diagram
EPJ Web of Conferences, 2015 I will review types of modes which are observed in stars with different masses and on various evolutionary stages. In particular, I will focus on energetic aspects of oscillation modes, i.e., excitation, distribution of kinetic energy, mode amplitude and
Daszyńska-Daszkiewicz Jadwiga
doaj +1 more source