Results 71 to 80 of about 3,729 (264)

Exploring the surface of HD 189733 via Doppler shadow analysis of planetary transits

Astronomy & Astrophysics
Context. Transmission spectroscopy has advanced our understanding of exoplanet atmospheres, but it can be hindered by contamination originating in stellar heterogeneities, mainly coming from line-of-sight effects.
Gonçalves E. C., Cristo E., Dethier W., Santos N. C., Sousa S. G., Viana P. T. P., Azevedo Silva T., Allart R., Bourrier V.   +8 more
doaj   +1 more source

The low dispersion synthetic spectra of cool giant stars

Odessa Astronomical Publications, 2017
he mean energy distribution of cool giant stars was used for comparison with synthetic spectra. The synthetic spectra was calculated using the various grids of stellar rnodel atrnospheres.
S. I. Belik, A. V. Dragunova, N. S. Komarov   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Semiempirical versus Theoretical Stellar Population Models: A Comparison with Star Clusters

The Astronomical Journal
Stellar population synthesis (SPS) models are a key tool for deriving the age, metallicity, radial velocity, and reddening of star clusters from their integrated spectra.
Randa Asa’d, Paula R. T. Coelho, Johina M. John, Igor V. Chilingarian, Gustavo Bruzual, Stephane Charlot   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

29. Stellar Spectra [PDF]

Transactions of the International Astronomical Union, 1982
During the interval covered by this report, Commission 29 has sponsored or cosponsored the following IAU meetings: Symposium 98 on “Be Stars,” Munich, FRG, April 1981; Colloquium 59, “Effects of Mass-Loss on Stellar Evolution,” Trieste, Italy, September 1980; and Colloquim 70, “The Nature of Symbiotic Stars,” Haute-Provence, France, August 1981.
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Metallicities and Refined Stellar Parameters for 52 Cool Dwarfs with Transiting Planets and Planet Candidates

The Astrophysical Journal Supplement Series
We collected near-infrared spectra of 65 cool stars with the NASA Infrared Telescope Facility and analyzed them to calculate accurate metallicities and stellar parameters.
Rebecca Gore, Steven Giacalone, Courtney D. Dressing, Emma V. Turtelboom, Ashley Schroeder, Charles D. Fortenbach, Kevin K. Hardegree-Ullman, Jon K. Zink, Andrew W. Mayo, Joshua E. Schlieder, Jessie L. Christiansen   +10 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source