Results 161 to 170 of about 1,100,727 (344)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Investigating Protostellar Accretion-driven Outflows across the Mass Spectrum: JWST NIRSpec Integral Field Unit 3–5 μm Spectral Mapping of Five Young Protostars

open access: yesThe Astrophysical Journal
Investigating Protostellar Accretion is a Cycle 1 JWST program using the NIRSpec+MIRI integral field units to obtain 2.9–28 μ m spectral cubes of five young protostars with luminosities of 0.2–10,000 L _⊙ in their primary accretion phase.
Samuel A. Federman   +38 more
doaj   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

open access: yesMolecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa   +14 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Stellar winds driven by Alfven waves [PDF]

open access: yes
Models of stellar winds were considered in which the dynamic expansion of a corona is driven by Alfven waves propagating outward along radial magnetic field lines.
Belcher, J. W., Olbert, S.
core   +1 more source

A Study of Emission Lines in Carbon Stars

open access: yesThe Astrophysical Journal
Carbon stars are chemically peculiar stars with high carbon abundance, showing strong carbon molecule bands and rare emission lines in their spectra. This paper explores the stellar activity of carbon stars by identifying emission line features in their ...
Lichan Zhou   +5 more
doaj   +1 more source

On the making of a PN: the interaction of a multiple stellar wind with the ISM

open access: hybrid, 2021
A. Manchado   +3 more
openalex   +1 more source

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