Results 141 to 150 of about 65,066 (300)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A Study of Emission Lines in Carbon Stars

The Astrophysical Journal
Carbon stars are chemically peculiar stars with high carbon abundance, showing strong carbon molecule bands and rare emission lines in their spectra. This paper explores the stellar activity of carbon stars by identifying emission line features in their ...
Lichan Zhou, Jianghui Cai, Haifeng Yang, Yuqing Yang, Xujun Zhao, Yaling Xun   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Measuring the magnetic fields in the chromospheres of low-mass stars [PDF]

Nat Commun
Cang T, Petit P, Donati J, Tian H, Fu J, Li H, Bellotti S, Hu X, Ma X, Ariste AL, Xing K, Morin J, Lu H, Zong W.   +13 more
europepmc   +2 more sources

PROJECT-J: The Shocking H2 Outflow from HH 46

The Astrophysical Journal
We analyze the H _2 emission observed in the HH 46 Class I system as part of PROtostellar JEts Cradle Tested with JWST (PROJECT-J), to investigate the origin and excitation of the warm molecular outflow. We used NIRSpec and MIRI spectral maps (1.6–27.9 μ
Maria Gabriela Navarro, Brunella Nisini, Teresa Giannini, Patrick J. Kavanagh, Alessio Caratti o Garatti, Simone Antoniucci, Hector G. Arce, Francesca Bacciotti, Sylvie Cabrit, Deirdre Coffey, Catherine Dougados, Jochen Eislöffel, Patrick Hartigan, Alberto Noriega- Crespo, Linda Podio, Ewine F. van Dishoeck, Emma T. Whelan   +16 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

An Extremely Young Protostellar Core, MMS 1/OMC-3: Episodic Mass Ejection History Traced by the Micro SiO Jet

The Astrophysical Journal
We present ∼0.″2 (∼80 au) resolution observations of the CO(2–1) and SiO(5–4) lines made with the Atacama large millimeter/submillimeter array toward an extremely young intermediate-mass protostellar source ( t _dyn < 1000 yr), MMS 1 located in the Orion
Satoko Takahashi, Masahiro N. Machida, Mitsuki Omura, Doug Johnstone, Kazuya Saigo, Naoto Harada, Kohji Tomisaka, Paul T. P. Ho, Luis A. Zapata, Steve Mairs, Gregory J. Herczeg, Kotomi Taniguchi, Yuhua Liu, Asako Sato   +13 more
doaj   +1 more source

Outlook for ultraviolet astronomy [PDF]

A brief overview of galactic and extragalactic research is given with emphasis on the problems of temperature determination, chemical abundance determination, and the question about the energy sources for the high temperature regions.
Boehm-Vitense, E.
core   +1 more source

Stellar Winds

The Astrophysical Journal, 1970
Peter Goldreich, William H. Julian
openaire   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source