Results 121 to 130 of about 5,969 (301)

Revisiting the evolutionary status of massive stars in the central parsec of the Milky Way

Astronomy & Astrophysics
Context. Massive stars and their winds strongly affect their environment. For example, they determine the accretion rate on to the Galactic centre (GC) supermassive black hole Sagittarius A* (Sgr A*).
Gormaz-Matamala A. C., Cuadra J., Kubátová B., Kubát J., Ekström S.   +4 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

The Milky Way Project MOBStIRS: Parameterizing Infrared Stellar-wind Bow Shock Morphologies with Citizen Science

The Astronomical Journal
Mass-loss influences stellar evolution, especially for massive stars with strong winds. Stellar wind bow shock nebulae driven by Galactic OB stars can be used to measure mass-loss rates ( $\dot{M}$ ).
Angelica S. Whisnant, Matthew S. Povich, Nikhil Patten, Henry A. Kobulnicky   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Discovery of a Collimated Jet from the Low-luminosity Protostar IRAS 16253−2429 in a Quiescent Accretion Phase with the JWST

The Astrophysical Journal Letters
Investigating Protostellar Accretion (IPA) is a JWST Cycle 1 GO program that uses NIRSpec integral field units and MIRI Medium Resolution Spectrograph to obtain 2.9–28 μ m spectral cubes of young, deeply embedded protostars with luminosities of 0.2–10 ...
Mayank Narang, P. Manoj, Himanshu Tyagi, Dan M. Watson, S. Thomas Megeath, Samuel Federman, Adam E. Rubinstein, Robert Gutermuth, Alessio Caratti o Garatti, Henrik Beuther, Tyler L. Bourke, Ewine F. Van Dishoeck, Neal J. Evans II, Guillem Anglada, Mayra Osorio, Thomas Stanke, James Muzerolle, Leslie W. Looney, Yao-Lun Yang, Pamela Klaassen, Nicole Karnath, Prabhani Atnagulov, Nashanty Brunken, William J. Fischer, Elise Furlan, Joel Green, Nolan Habel, Lee Hartmann, Hendrik Linz, Pooneh Nazari, Riwaj Pokhrel, Rohan Rahatgaonkar, Will R. M. Rocha, Patrick Sheehan, Katerina Slavicinska, Amelia M. Stutz, John J. Tobin, Lukasz Tychoniec, Scott Wolk   +38 more
doaj   +1 more source

The star formation factory revisited

Astronomy & Astrophysics
Context. Stellar feedback regulates star formation and shapes the interstellar medium, yet its role during the collapse of molecular clouds remains uncertain over a wide range of initial conditions. Aims.
Jiménez S., Kománek D., Wünsch R., Palouš J., Ehlerová S., Martínez-González S., Srbljanović A.   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Constraining the Diffusion Coefficient and Cosmic-Ray Acceleration Efficiency Using Gamma-Ray Emission from the Star-forming Region RCW 38

The Astrophysical Journal
Stellar winds from massive stars may be significant sources of cosmic rays (CRs). To investigate this connection, we report a detailed study of gamma-ray emission near the young Milky Way star cluster (≈0.5 Myr old) in the star-forming region RCW 38 and ...
Paarmita Pandey, Laura A. Lopez, Anna L. Rosen, Todd A. Thompson, Tim Linden, Ian Blackstone   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A survey of stellar winds for young, Sun-like stars

, 2018
The Starwinds project at the University of Southern Queensland intends to produce the largest atlas of three-dimensional wind maps of young, Sun-like stars to date.
Evensberget, Dag Frohde, Evensberget, Dag Frohde (5944124)   +1 more
core   +1 more source