Results 101 to 110 of about 5,969 (301)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Galactic centre stellar winds and Sgr A* accretion

, 2005
We present a detailed discussion of our new 3D numerical models for the accretion of stellar winds on to Sgr A. In our most sophisticated models, we put stellar wind sources on realistic orbits around Sgr A, we include recently discovered `slow &apos ...
Tiziana Di Matteoy, Cuadra, Jorge, Nayakshin, Sergei, Cuadra, J., Nayakshin, S., Di Matteo, Tiziana, Sergei Nayakshinx, Springel, Volker, Di Matteo, T., Volker Springel, Jorge Cuadraz, Springel, V.   +11 more
core   +1 more source

Weakened Magnetic Braking in the Exoplanet Host Star 51 Peg

The Astrophysical Journal Letters
The consistently low activity level of the old solar analog 51 Peg not only facilitated the discovery of the first hot Jupiter, but also led to the suggestion that the star could be experiencing a magnetic grand minimum.
Travis S. Metcalfe, Klaus G. Strassmeier, Ilya V. Ilyin, Derek Buzasi, Oleg Kochukhov, Thomas R. Ayres, Sarbani Basu, Ashley Chontos, Adam J. Finley, Victor See, Keivan G. Stassun, Jennifer L. van Saders, Aldo G. Sepulveda, George R. Ricker   +13 more
doaj   +1 more source

The theory of stellar winds [PDF]

Astrophysics and Space Science, 2011
We present a brief overview of the theory of stellar winds with a strong emphasis on the radiation-driven outflows from massive stars. The resulting implications for the evolution and fate of massive stars are also discussed. Furthermore, we relate the effects of mass loss to the angular momentum evolution, which is particularly relevant for the ...
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

THE CONTRIBUTION OF STELLAR WINDS TO COSMIC RAY PRODUCTION

, 2018
Massive stars blow powerful stellar winds throughout, their evolutionary stages from the main sequence to Wolf-Rayet phases. The amount of mechanical energy deposited in the interstellar medium by the wind from a massive star can be comparable to the ...
Kang, Hyesung, Seo, Jeongbhin, Ryu, Dongsu   +2 more
core   +1 more source

Clumps in stellar winds [PDF]

ASTRA Proceedings, 2014
Abstract. We discuss the origin and quantification of wind clumping and mass–loss rates (Ṁ), particularly in close proximity to the Eddington (Γ) limit, relevant for very massive stars (VMS). We present evidence that clumping may not be the result of the line-deshadowing instability (LDI), but that clumps are already present in the stellar photosphere.
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Accretion and Recovery in Giant Eruptions of Massive Stars

The Astrophysical Journal
Giant eruptions are episodic high-rate mass-loss events that massive stars experience in the late-stage of their evolution before exploding as a core-collapse supernova.
Bhawna Mukhija, Amit Kashi
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source