Results 111 to 120 of about 1,187 (260)

MINDS. JWST-MIRI Observations of a Spatially Resolved Atomic Jet and Polychromatic Molecular Wind toward SY Cha

open access: yesThe Astrophysical Journal
The removal of angular momentum from protostellar systems drives accretion onto the central star and may drive the dispersal of the protoplanetary disk. Winds and jets can contribute to removing angular momentum from the disk, though the dominant process
Kamber R. Schwarz   +23 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Investigating Protostellar Accretion-driven Outflows across the Mass Spectrum: JWST NIRSpec Integral Field Unit 3–5 μm Spectral Mapping of Five Young Protostars

open access: yesThe Astrophysical Journal
Investigating Protostellar Accretion is a Cycle 1 JWST program using the NIRSpec+MIRI integral field units to obtain 2.9–28 μ m spectral cubes of five young protostars with luminosities of 0.2–10,000 L _⊙ in their primary accretion phase.
Samuel A. Federman   +38 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Stellar-wind-blown Bubbles as Environments for Late-time Rebrightening of Gamma-ray Burst Afterglows

open access: yesThe Astrophysical Journal Letters
We present multiwavelength afterglow fitting results for three events that exhibit late afterglow rebrightening behavior: EP240414a ( z = 0.401), GRB 240529A ( z = 2.695), and GRB 240218A ( z = 6.782), which span a broad range of redshifts, from the ...
Jia Ren   +7 more
doaj   +1 more source

Stellar Winds

open access: yesThe Astrophysical Journal, 1970
Peter Goldreich, William H. Julian
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Measuring the magnetic fields in the chromospheres of low-mass stars [PDF]

open access: yesNat Commun
Cang T   +13 more
europepmc   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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