Results 111 to 120 of about 1,192 (260)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Rotational Evolution of Classical T Tauri Stars: Models and Observations
The Astrophysical JournalWe developed a grid of stellar rotation models for low-mass and solar-type classical T Tauri stars (CTTS; 0.3 M _⊙ < M _* < 1.2 M _⊙ ). These models incorporate the star–disk interaction and magnetospheric ejections to investigate the evolution of the ...
Javier Serna +19 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Weakened Magnetic Braking Signals the Collapse of the Global Stellar Dynamo
The Astrophysical Journal LettersWeakened magnetic braking (WMB) was originally proposed in 2016 to explain anomalously rapid rotation in old field stars observed by the Kepler mission.
Travis S. Metcalfe +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Observations of Extremely Metal-poor O Stars: Weak Winds and Constraints for Evolution Models
The Astrophysical JournalMetal-poor massive stars drive the evolution of low-mass galaxies, both locally and at high redshift. However, quantifying the feedback they impart to their local surroundings remains uncertain because models of stellar evolution, mass loss, and ionizing
O. Grace Telford +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
The Astrophysical JournalThe removal of angular momentum from protostellar systems drives accretion onto the central star and may drive the dispersal of the protoplanetary disk. Winds and jets can contribute to removing angular momentum from the disk, though the dominant process
Kamber R. Schwarz +23 more
doaj +1 more source