Results 111 to 120 of about 65,066 (300)

The Milky Way Project MOBStIRS: Parameterizing Infrared Stellar-wind Bow Shock Morphologies with Citizen Science

The Astronomical Journal
Mass-loss influences stellar evolution, especially for massive stars with strong winds. Stellar wind bow shock nebulae driven by Galactic OB stars can be used to measure mass-loss rates ( $\dot{M}$ ).
Angelica S. Whisnant, Matthew S. Povich, Nikhil Patten, Henry A. Kobulnicky   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Discovery of a Collimated Jet from the Low-luminosity Protostar IRAS 16253−2429 in a Quiescent Accretion Phase with the JWST

The Astrophysical Journal Letters
Investigating Protostellar Accretion (IPA) is a JWST Cycle 1 GO program that uses NIRSpec integral field units and MIRI Medium Resolution Spectrograph to obtain 2.9–28 μ m spectral cubes of young, deeply embedded protostars with luminosities of 0.2–10 ...
Mayank Narang, P. Manoj, Himanshu Tyagi, Dan M. Watson, S. Thomas Megeath, Samuel Federman, Adam E. Rubinstein, Robert Gutermuth, Alessio Caratti o Garatti, Henrik Beuther, Tyler L. Bourke, Ewine F. Van Dishoeck, Neal J. Evans II, Guillem Anglada, Mayra Osorio, Thomas Stanke, James Muzerolle, Leslie W. Looney, Yao-Lun Yang, Pamela Klaassen, Nicole Karnath, Prabhani Atnagulov, Nashanty Brunken, William J. Fischer, Elise Furlan, Joel Green, Nolan Habel, Lee Hartmann, Hendrik Linz, Pooneh Nazari, Riwaj Pokhrel, Rohan Rahatgaonkar, Will R. M. Rocha, Patrick Sheehan, Katerina Slavicinska, Amelia M. Stutz, John J. Tobin, Lukasz Tychoniec, Scott Wolk   +38 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Constraining the Diffusion Coefficient and Cosmic-Ray Acceleration Efficiency Using Gamma-Ray Emission from the Star-forming Region RCW 38

The Astrophysical Journal
Stellar winds from massive stars may be significant sources of cosmic rays (CRs). To investigate this connection, we report a detailed study of gamma-ray emission near the young Milky Way star cluster (≈0.5 Myr old) in the star-forming region RCW 38 and ...
Paarmita Pandey, Laura A. Lopez, Anna L. Rosen, Todd A. Thompson, Tim Linden, Ian Blackstone   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Aperture and Resolution Effects on Ultraviolet Star-forming Properties: Insights from Local Galaxies and Implications for High-redshift Observations

The Astrophysical Journal
We present an analysis of the effects of spectral resolution and aperture scale on derived galaxy properties using far-ultraviolet (FUV) spectra of local star-forming galaxies from the International Ultraviolet Explorer ( R ∼ 250, field of view (FOV ...
Ilyse Clark, Danielle A. Berg, Claus Leitherer, Karla Z. Arellano-Córdova, Andreas A. C. Sander   +4 more
doaj   +1 more source

Relativistic Stellar-Wind Torques

The Astrophysical Journal, 1969
Solar wind-induced torque calculated considering special and general relativistic effects, extending method to pulsar rotational ...
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The Stellar-Wind Regions.

The Astrophysical Journal, 1961
Abstract : WITH CLASS G main sequence and M-giant stars are given for various interst llar environments. The supersonic wind from a class G star undergoes a shock transition to subsonic flow at a radial distance of 100 - 1,000 a.u. and may extend many times farther as a subsonic flow. Thic storms. Open-ended Terms: Stellar Wind.
openaire   +1 more source