Results 131 to 140 of about 242,475 (295)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

MINDS. JWST-MIRI Observations of a Spatially Resolved Atomic Jet and Polychromatic Molecular Wind toward SY Cha

The Astrophysical Journal
The removal of angular momentum from protostellar systems drives accretion onto the central star and may drive the dispersal of the protoplanetary disk. Winds and jets can contribute to removing angular momentum from the disk, though the dominant process
Kamber R. Schwarz, Matthias Samland, Göran Olofsson, Thomas Henning, Andrew Sellek, Manuel Güdel, Benoît Tabone, Inga Kamp, Pierre-Olivier Lagage, Ewine F. van Dishoeck, Alessio Caratti o Garatti, Adrian M. Glauser, Tom P. Ray, Aditya M. Arabhavi, Valentin Christiaens, R. Franceschi, Danny Gasman, Sierra L. Grant, Jayatee Kanwar, Till Kaeufer, Nicolas T. Kurtovic, Giulia Perotti, Milou Temmink, Marissa Vlasblom   +23 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Investigating Protostellar Accretion-driven Outflows across the Mass Spectrum: JWST NIRSpec Integral Field Unit 3–5 μm Spectral Mapping of Five Young Protostars

The Astrophysical Journal
Investigating Protostellar Accretion is a Cycle 1 JWST program using the NIRSpec+MIRI integral field units to obtain 2.9–28 μ m spectral cubes of five young protostars with luminosities of 0.2–10,000 L _⊙ in their primary accretion phase.
Samuel A. Federman, S. Thomas Megeath, Adam E. Rubinstein, Robert Gutermuth, Mayank Narang, Himanshu Tyagi, P. Manoj, Guillem Anglada, Prabhani Atnagulov, Henrik Beuther, Tyler L. Bourke, Nashanty Brunken, Alessio Caratti o Garatti, Neal J. Evans II, William J. Fischer, Elise Furlan, Joel D. Green, Nolan Habel, Lee Hartmann, Nicole Karnath, Pamela Klaassen, Hendrik Linz, Leslie W. Looney, Mayra Osorio, James Muzerolle Page, Pooneh Nazari, Riwaj Pokhrel, Rohan Rahatgaonkar, Will R. M. Rocha, Patrick Sheehan, Katerina Slavicinska, Thomas Stanke, Amelia M. Stutz, John J. Tobin, Lukasz Tychoniec, Ewine F. Van Dishoeck, Dan M. Watson, Scott Wolk, Yao-Lun Yang   +38 more
doaj   +1 more source

Stellar Winds

The Astrophysical Journal, 1970
Peter Goldreich, William H. Julian
openaire   +1 more source

Simulating supernova feedback in galaxy disks [PDF]

, 2012
In this thesis I examine supernova feedback in hydrodynamical simulations of galaxy disks. Understanding this process entails the numerical evaluation of cooling in radiative shocks, and we present a set of simulations using two widely used numerical ...
CREASEY, PETER,EDWARD, Creasey, Peter Edward   +1 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Radiatively Driven Stellar Winds from Hot Stars

, 2008
A stellar wind is the continuous, supersonic outflow of matter from a star. Among the most massive stars—which tend also to be the hottest and most luminous—the winds can be very strong, with important consequences both for the star’s own evolution as ...

core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source