Results 91 to 100 of about 242,475 (295)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Weakened Magnetic Braking in the Exoplanet Host Star 51 Peg

The Astrophysical Journal Letters
The consistently low activity level of the old solar analog 51 Peg not only facilitated the discovery of the first hot Jupiter, but also led to the suggestion that the star could be experiencing a magnetic grand minimum.
Travis S. Metcalfe, Klaus G. Strassmeier, Ilya V. Ilyin, Derek Buzasi, Oleg Kochukhov, Thomas R. Ayres, Sarbani Basu, Ashley Chontos, Adam J. Finley, Victor See, Keivan G. Stassun, Jennifer L. van Saders, Aldo G. Sepulveda, George R. Ricker   +13 more
doaj   +1 more source

Thermospheric winds and temperatures above Mawson, Antarctica, observed with an all-sky imaging, Fabry-Perot spectrometer [PDF]

, 2009
A new all-sky imaging Fabry-Perot spectrometer has been installed at Mawson station (67°36' S, 62°52' E), Antarctica. This instrument is capable of recording independent spectra from many tens of locations across the sky simultaneously.
Anderson, C., Kosch, M.J., P. Dyson, Davies, T., M. J. Kosch, Conde, M., Dyson, P., M. Conde, C. Anderson, T. Davies   +9 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

X-raying clumped stellar winds

, 2008
X-ray spectroscopy is a sensitive probe of stellar winds. X-rays originate from optically thin shock-heated plasma deep inside the wind and propagate outwards throughout absorbing cool material. Recent analyses of the line ratios from He-like ions in the
Feldmeier, Achim (Prof. Dr.), Hamann, Wolf-Rainer (Prof. Dr.), Oskinova, Lidia M. (Dr.)   +2 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Stellar winds of hot stars

, 2015
In this paper, we summarize the basic properties of radiative stellar winds from the theoretical and observational point of views. We illustrate two examples of a radiative code applied to stellar physics: the SIMECA code successfully used to constrain ...
Ph. Stee, O. Chesneau
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Accretion and Recovery in Giant Eruptions of Massive Stars

The Astrophysical Journal
Giant eruptions are episodic high-rate mass-loss events that massive stars experience in the late-stage of their evolution before exploding as a core-collapse supernova.
Bhawna Mukhija, Amit Kashi
doaj   +1 more source

The Stellar-Wind Regions.

The Astrophysical Journal, 1961
Abstract : WITH CLASS G main sequence and M-giant stars are given for various interst llar environments. The supersonic wind from a class G star undergoes a shock transition to subsonic flow at a radial distance of 100 - 1,000 a.u. and may extend many times farther as a subsonic flow. Thic storms. Open-ended Terms: Stellar Wind.
openaire   +1 more source