Results 91 to 100 of about 65,066 (300)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Weakened Magnetic Braking in the Exoplanet Host Star 51 Peg

The Astrophysical Journal Letters
The consistently low activity level of the old solar analog 51 Peg not only facilitated the discovery of the first hot Jupiter, but also led to the suggestion that the star could be experiencing a magnetic grand minimum.
Travis S. Metcalfe, Klaus G. Strassmeier, Ilya V. Ilyin, Derek Buzasi, Oleg Kochukhov, Thomas R. Ayres, Sarbani Basu, Ashley Chontos, Adam J. Finley, Victor See, Keivan G. Stassun, Jennifer L. van Saders, Aldo G. Sepulveda, George R. Ricker   +13 more
doaj   +1 more source

Stellar mass-loss near the Eddington limit. Tracing the sub-photospheric layers of classical Wolf-Rayet stars

, 2013
Towards the end of their evolution hot massive stars develop strong stellar winds and appear as emission line stars, such as WR stars or LBVs. The quantitative description of the mass loss in these important pre-SN phases is hampered by unknowns such as ...
Gräfener, G., Vink, J. S.
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Constraining Stellar Winds of Young Sun-like Stars

, 2013
As part of the project Pathways to Habitability (http://path.univie.ac.at/), we study the properties of the stellar winds of low-mass and Sun-like stars, and their influences on the atmospheres of potentially habitable planets.
Fichtinger, Bibiana, Güdel, Manuel, Johnstone, Colin P., Lüftinger, Theresa   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Accretion and Recovery in Giant Eruptions of Massive Stars

The Astrophysical Journal
Giant eruptions are episodic high-rate mass-loss events that massive stars experience in the late-stage of their evolution before exploding as a core-collapse supernova.
Bhawna Mukhija, Amit Kashi
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A Monopolar Jet from Protostar HOPS 10: Evidence for Asymmetric Magnetized Launching

The Astronomical Journal
A fundamental challenge in star formation is understanding how a protostar accretes mass from its circumstellar disk while removing excess angular momentum.
Somnath Dutta
doaj   +1 more source

Collective non-thermal emission from an extragalactic jet interacting with stars

, 2017
The central regions of galaxies are complex environments, rich in evolved and/or massive stars. For galaxies hosting an active galactic nucleus (AGN) with jets, the interaction of the jets with the winds of the stars within can lead to particle ...
Bosch-Ramon, Valentí, Torres-Albà, Núria, Vieyro, Florencia L.   +2 more
core   +1 more source