Results 71 to 80 of about 242,475 (295)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Investigating the Nested Structure of the Outflow from the Low Luminosity Protostar IRAS 16253-2429 Using JWST and ALMA

The Astrophysical Journal
Understanding the earliest stage of star and planet formation requires detailed observations to address the connection and interplay between the accretion, outflow, and disk evolution.
Mayank Narang, Himanshu Tyagi, Nagayoshi Ohashi, P. Manoj, S. Thomas Megeath, John J. Tobin, Ewine F. Van Dishoeck, Neal J. Evans II, Dan M. Watson, Alessio Caratti o Garatti, Jes K. Jørgensen, Robert Gutermuth, Yusuke Aso, Henrik Beuther, Leslie W. Looney, David A. Neufeld, Guillem Anglada, Mayra Osorio, Adam E. Rubinstein, Samuel Federman, Lee W. Hartmann, Pooneh Nazari, Nicole Karnath, Hendrik Linz, Thomas Stanke, Tyler L. Bourke, Yao-Lun Yang, Rolf Kuiper, Joel Green, Pamela Klaassen, Wafa Zakri, Nolan Habel, Nashanty Brunken, James Muzerolle, Katerina Slavicinska, Amelia M. Stutz, Lukasz Tychoniec, Scott Wolk, Will R. M. Rocha, William J. Fischer   +39 more
doaj   +1 more source

Solar and stellar coronae and winds

, 2016
Solar-like stars influence their environments through their coronal emis- sion and winds. These processes are linked through the physics of the stellar magnetic field, whose strength and geometry has now been explored for a large number of stars through ...
Moira Jardine
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Young Stellar Clusters with a Schuster Mass Distribution - I: Stationary Winds

, 2013
Hydrodynamic models for spherically-symmetric winds driven by young stellar clusters with a generalized Schuster stellar density profile are explored. For this we use both semi-analytic models and 1D numerical simulations.
GUILLERMO TENORIO TAGLE, SERGIO MARTINEZ GONZALEZ, SERGIY SILICH   +2 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Spin-down of Solar-mass Protostars in Magnetospheric Accretion Paradigm

The Astrophysical Journal
Stellar spin is one of the fundamental quantities that characterize a star itself and its planetary system. Nevertheless, stellar spin-down mechanisms in protostellar and pre-main-sequence stellar phases have been a long-standing problem in star ...
Shinsuke Takasao, Masanobu Kunitomo, Takeru K. Suzuki, Kazunari Iwasaki, Kengo Tomida   +4 more
doaj   +1 more source

STELLAR WIND IN THE ISM

Odessa Astronomical Publications, 2017
After a brief review of the modern understanding of stellar wind's action on the ISM we consider two aspects of its "global" collective effect from observational viewpoint.
T. A. Lozinskaya
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

An Embedded Disk (eDisk) in the IceAge: Investigating the Jet and Outflow from Ced 110 IRS4

The Astronomical Journal
We present a comprehensive study of the large-scale structure, jet and outflow morphology, and kinematics of the Class 0/I protostellar binary Ced 110 IRS4, using JWST NIRCam (F150W and F410M) and MIRI MRS observations from the JWST ERC program IceAge ...
Mayank Narang, Nagayoshi Ohashi, John J. Tobin, M. K. McClure, Jes K. Jørgensen, Jinshi Sai (Insa Choi), eDisk + IceAge Team   +6 more
doaj   +1 more source