Results 81 to 90 of about 65,066 (300)
A Cosmic Ray Resolution to the Superbubble Energy-Crisis
, 2008 Superbubbles (SBs) are amongst the greatest injectors of energy into the Galaxy, and have been proposed to be the acceleration site of Galactic cosmic rays.
Andrei M. Bykov +10 more
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
, 2014 X-ray emission from stars much more massive than the Sun was discovered only 35 years ago. Such stars drive fast stellar winds where shocks can develop, and it is commonly assumed that the X-rays emerge from the shock-heated plasma.
Hamann, Wolf-Rainer +6 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The winds and coronae of early-type stars [PDF]
, 1983 The properties of the winds of hot stars as derived from radio, ultraviolet and X-ray observations is presented. Special focus is given to observations that test line driven wind theory.
Cassinelli, J. P.
core +1 more source
This is a pre-print of a chapter for the Encyclopedia of Astrophysics (edited by I. Mandel, section editor F.R.N.
openaire +2 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Molecules in Stellar Winds [PDF]
Symposium - International Astronomical Union, 1992 High mass-loss molecular winds are characterstic of two important phases of stellar evolution, very young protostars and stars on the asymptotic branch. Novel chemical processes in these winds suggest a variety of new astronomical observations.
openaire +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Testing the Rossby Paradigm: Weakened Magnetic Braking in Early K-type Stars
The Astrophysical JournalThere is an intricate relationship between the organization of large-scale magnetic fields by a stellar dynamo and the rate of angular momentum loss due to magnetized stellar winds. An essential ingredient for the operation of a large-scale dynamo is the
Travis S. Metcalfe +14 more
doaj +1 more source