Results 81 to 90 of about 1,187 (260)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Ages and zero age main sequence spin distribution of stars in detached eclipsing binaries
Astronomy & AstrophysicsBenchmarking fundamental stellar properties is essential for calibrating evolutionary models and establishing empirical relationships between mass, radius, luminosity, and related stellar properties.
Merle T. +6 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Bubble and Outflow in S Mon Revealed by Multiband Data Sets
The Astrophysical JournalWe identify a molecular bubble, and study the star formation and its feedback in the S Mon region, using multiple molecular lines, young stellar objects (YSOs), and infrared data.
Dejian Liu +10 more
doaj +1 more source
Revisiting the evolutionary status of massive stars in the central parsec of the Milky Way
Astronomy & AstrophysicsContext. Massive stars and their winds strongly affect their environment. For example, they determine the accretion rate on to the Galactic centre (GC) supermassive black hole Sagittarius A* (Sgr A*).
Gormaz-Matamala A. C. +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
The Astronomical JournalMass-loss influences stellar evolution, especially for massive stars with strong winds. Stellar wind bow shock nebulae driven by Galactic OB stars can be used to measure mass-loss rates ( $\dot{M}$ ).
Angelica S. Whisnant +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
The Astrophysical Journal LettersInvestigating Protostellar Accretion (IPA) is a JWST Cycle 1 GO program that uses NIRSpec integral field units and MIRI Medium Resolution Spectrograph to obtain 2.9–28 μ m spectral cubes of young, deeply embedded protostars with luminosities of 0.2–10 ...
Mayank Narang +38 more
doaj +1 more source