Results 111 to 120 of about 2,711,256 (365)

Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress

Cell Communication and Signaling
Background Olanzapine (OLZ) reverses chronic stress-induced anxiety. Chronic stress promotes cancer development via abnormal neuro-endocrine activation.
Jinxin Lu, Xiaoyu Zhang, Keyu Su, Huandong Luo, Congcong Liu, Yuqing Yang, Bin He, Cenxin Wang, Zhuoran Zhao, Xianxian Liu, Xu Wang, Peixuan Meng, Dekang Lv, Chunli Wang, Keith W. Kelley, Ling Wang, Bai Cui, Quentin Liu, Fei Peng   +18 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

SINGLE INTRACAVERNOUS INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED STEM CELLS VERSUS A SINGLE HIGH DOSE OF PLATELET RICH PLASMA TO IMPROVE ERECTILE DYSFUNCTION: A COMPARATIVE STUDY

Continence, 2023
H Bailly, M Abou Chakra, F Schill, B Dabboucy, C Khalil, M Lorenz, N Rodehutskors, J Boaz, M Jida, N El Beayni, K Ismail, E Hanna, L Hage, A Abo Yassine, G Delavar, A Popescu, M Moussa   +16 more
doaj   +1 more source

Self-diploidization of human haploid parthenogenetic embryos through the Rho pathway regulates endomitosis and failed cytokinesis

Scientific Reports, 2017
A diploid genome is necessary for normal mammalian development, thus haploid parthenogenetic embryos undergo frequent self-diploidization during preimplantation development; however, the underlying mechanism is unclear.
Lizhi Leng, Qi Ouyang, Xiangyi Kong, Fei Gong, Changfu Lu, Lei Zhao, Yun Shi, Dehua Cheng, Liang Hu, Guangxiu Lu, Ge Lin   +10 more
doaj   +1 more source

The Histone 3'-Terminal Stem-Loop-Binding Protein Enhances Translation through a Functional and Physical Interaction with Eukaryotic Initiation Factor 4G (eIF4G) and eIF3 [PDF]

, 2002
Metazoan cell cycle-regulated histone mRNAs are unique cellular mRNAs in that they terminate in a highly conserved stem-loop structure instead of a poly(A) tail.
Gallie, Daniel R, Ling, Jun, Marzluff, William F, Morley, Simon J, Pain, Virginia M   +4 more
core   +4 more sources

Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target [PDF]

, 2015
Yongmin Yan, Xiangsheng Zuo, Daoyan Wei
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials [PDF]

, 2016
Li‐Tzu Wang, Chiao-Hsuan Ting, Ming‐Shyen Yen, Ko‐Jiunn Liu, Huey‐Kang Sytwu, Kenneth K. Wu, B. Linju Yen   +6 more
openalex   +1 more source