Results 111 to 120 of about 1,455,444 (317)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Fresh or frozen? Classifying ‘spare' embryos for donation to human embryonic stem cell research [PDF]

, 2010
This article is available open access, funded by the Wellcome Trust. It is distributed under a Creative Commons License (http://creativecommons.org/licenses/by/3.0/). Copyright @ 2010 Elsevier Ltd.United Kingdom (UK) funding to build human embryonic stem
Williams, C, Clare Williams, Farsides, Bobbie, Kathryn Ehrich (16049615), Ehrich, K, Ehrich, Kathryn, Williams, Clare, Kathryn Ehrich, Bobbie Farsides, Clare Williams (14068554), Farsides, B, Bobbie Farsides (4461928)   +11 more
core   +1 more source

Self-diploidization of human haploid parthenogenetic embryos through the Rho pathway regulates endomitosis and failed cytokinesis

Scientific Reports, 2017
A diploid genome is necessary for normal mammalian development, thus haploid parthenogenetic embryos undergo frequent self-diploidization during preimplantation development; however, the underlying mechanism is unclear.
Lizhi Leng, Qi Ouyang, Xiangyi Kong, Fei Gong, Changfu Lu, Lei Zhao, Yun Shi, Dehua Cheng, Liang Hu, Guangxiu Lu, Ge Lin   +10 more
doaj   +1 more source

The Stem Cells and the Cancer Stem Cells [PDF]

Journal of Gynecology and Womens Health, 2019
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openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Nanotechnology Applied to Stem Cell-Substratum Interactions [PDF]

, 2008
The modulation of biological interaction with artificial surfaces is a vital aspect of biomaterials research. Perhaps the most challenging area is transplantation involving the introduction of stem cells into the body with their ability to ...
Aref, Amirreza
core  

Media presentation and public understanding of stem cells and stem cell research in Hungary

, 2011
This paper reports on a research project which examined media coverage and audience perceptions of stem cells and stem cell research in Hungary, using focus groups and a media analysis. A background study was also conducted on the Hungarian legal, social
Lilla Vicsek, Júlia Gergely, Vicsek, Lilla, Gergely, Júlia   +3 more
core   +1 more source

SINGLE INTRACAVERNOUS INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED STEM CELLS VERSUS A SINGLE HIGH DOSE OF PLATELET RICH PLASMA TO IMPROVE ERECTILE DYSFUNCTION: A COMPARATIVE STUDY

Continence, 2023
H Bailly, M Abou Chakra, F Schill, B Dabboucy, C Khalil, M Lorenz, N Rodehutskors, J Boaz, M Jida, N El Beayni, K Ismail, E Hanna, L Hage, A Abo Yassine, G Delavar, A Popescu, M Moussa   +16 more
doaj   +1 more source

Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress

Cell Communication and Signaling
Background Olanzapine (OLZ) reverses chronic stress-induced anxiety. Chronic stress promotes cancer development via abnormal neuro-endocrine activation.
Jinxin Lu, Xiaoyu Zhang, Keyu Su, Huandong Luo, Congcong Liu, Yuqing Yang, Bin He, Cenxin Wang, Zhuoran Zhao, Xianxian Liu, Xu Wang, Peixuan Meng, Dekang Lv, Chunli Wang, Keith W. Kelley, Ling Wang, Bai Cui, Quentin Liu, Fei Peng   +18 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source