Results 71 to 80 of about 1,165,162 (267)

Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

Nature Communications, 2016
Rett syndrome is a neurodevelopmental disorder caused by mutations in Mecp2. Here the authors show that Mecp2 loss-of-function leads to upregulation of the NF-κB pathway, and that reducing NF-κB signalling ameliorates phenotypes of Mecp2-null mice, thus ...
Noriyuki Kishi, Jessica L. MacDonald, Julia Ye, Bradley J. Molyneaux, Eiman Azim, Jeffrey D. Macklis   +5 more
doaj   +1 more source

Development and Implementation of a Disease‐Targeted Storybook as a Clinical Tool for Children With Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Although significant progress has been made in childhood leukemia survival, healthcare providers, and caregivers often face challenges in explaining this disease to patients. Disease‐targeted storybooks have been proposed as a tool to facilitate the understanding of diagnoses and treatment.
Nutvipha Ummartyotin, Usanarat Anurathapan, Rawiwan Roongpraiwan, Potchanee Dandamrongrak, Siriporn Nakhonchai, Pawin Numthavaj, Vilawan Chirdkiatgumchai   +6 more
wiley   +1 more source

METTL14 regulates chondrogenesis through the GDF5–RUNX–extracellular matrix gene axis during limb development

Nature Communications
m6A RNA methylation is essential for many aspects of mammalian development but its roles in chondrogenesis remain largely unknown. Here, we show that m6A is necessary for chondrogenesis and limb morphogenesis using limb progenitor-specific knockout mice ...
Nobuko Katoku-Kikyo, Hiroko Kawakami, Max Cantor, Yasuhiko Kawakami, Nobuaki Kikyo   +4 more
doaj   +1 more source

Generation of footprint-free human induced pluripotent stem cell line (SCIKFi001-B) from cGMP grade umbilical cord-derived mesenchymal stem cells (UC-MSCs) using episomal-plasmid based reprogramming approach

Stem Cell Research
UCMSCs were reprogrammed to iPSCs using Yamanaka factor bearing episomal plasmids. SCIKFi001-B exhibited pluripotency, had typical iPSC morphology and didn’t retain any residual episomal plasmid.
Marchella Tohari, Ricky Sanjaya, Siska Yuliana Sari, Bintang Tedjobagaskara, Andrian Ibnu Faisal, Matheus Alvin Prawira, Anggia Oktaviani Dwi Putri, Naufalia Faza, Harry Murti, Halida P. Widyastuti   +9 more
doaj   +1 more source

Skeletal Stem Cells

Development, 2004
Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marrow ...
BIANCO, Paolo, P.G. Robey
openaire   +4 more sources

A Population‐Based Study on Childhood Aplastic Anemia—Incidence, Outcomes, and Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood aplastic anemia (AA) is a rare disease, and both the disease itself and its treatment cause significant morbidity. We aimed to determine the contemporary incidence of childhood AA in Finland, to compare the clinical characteristics of AA against inherited bone marrow failure syndromes (IBMFS) and refractory cytopenia of ...
Lauri‐Matti Kulmala, Riitta Niinimäki, Tytti Pokka, Anu Huurre, Liisa Järvelä, Sauli Palmu, Tuuli Pöyhönen, Pauliina Utriainen, Henri Aarnivala   +8 more
wiley   +1 more source

SINGLE INTRACAVERNOUS INJECTION OF AUTOLOGOUS ADIPOSE-DERIVED STEM CELLS VERSUS A SINGLE HIGH DOSE OF PLATELET RICH PLASMA TO IMPROVE ERECTILE DYSFUNCTION: A COMPARATIVE STUDY

Continence, 2023
H Bailly, M Abou Chakra, F Schill, B Dabboucy, C Khalil, M Lorenz, N Rodehutskors, J Boaz, M Jida, N El Beayni, K Ismail, E Hanna, L Hage, A Abo Yassine, G Delavar, A Popescu, M Moussa   +16 more
doaj   +1 more source

Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress

Cell Communication and Signaling
Background Olanzapine (OLZ) reverses chronic stress-induced anxiety. Chronic stress promotes cancer development via abnormal neuro-endocrine activation.
Jinxin Lu, Xiaoyu Zhang, Keyu Su, Huandong Luo, Congcong Liu, Yuqing Yang, Bin He, Cenxin Wang, Zhuoran Zhao, Xianxian Liu, Xu Wang, Peixuan Meng, Dekang Lv, Chunli Wang, Keith W. Kelley, Ling Wang, Bai Cui, Quentin Liu, Fei Peng   +18 more
doaj   +1 more source

The Stem Cells and the Cancer Stem Cells [PDF]

Journal of Gynecology and Womens Health, 2019
n ...
openaire   +2 more sources

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source