Results 81 to 90 of about 817,109 (355)
Cancer stem cell and niche [PDF]
Frontiers in Bioscience, 2010 Recent research on cancer has generated a new model for cancer growth-cancer stem cell model. This model can explain the inefficiency of conventional therapy. Tumor tissue, like normal tissue, is continuously repopulated from pools of self-renewing stem cells growing in a "niche", which is made up of a specialized vascular bed of endothelial cells ...
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Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Matrix Biology, 2014 Tenascins are extracellular matrix proteins with distinct spatial and temporal expression during development, tissue homeostasis and disease. Based on their expression patterns and knockout phenotypes an important role of tenascins in tissue formation, cell adhesion modulation, regulation of proliferation and differentiation has been demonstrated.
Chiquet-Ehrismann Ruth +4 more
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The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Signaling in the stem cell niche: regulating cell fate, function and plasticity
Development, 2018 Stem cells have the ability to self-renew and differentiate along multiple lineages, driving tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical differentiation trajectories observed in embryonic and hematopoietic stem cells ...
C. A. Chacón‐Martínez +2 more
semanticscholar +1 more source
Hematopoietic stem cell niches [PDF]
SCIENTIA SINICA Vitae, 2017 Hematopoietic stem cells (HSC) reside at the apex of the hematopoietic hierarchy, with self-renewal and differentiation potential, and are widely used in clinic. Studies in the past few decades have confirmed that the functional characteristics of HSC are not only controlled by intrinsic factors, but also supported and nourished by extrinsic ...
Hui CHENG, Tao CHENG
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
Testicular endothelial cells are a critical population in the germline stem cell niche
Nature Communications, 2018 Maintenance of adult tissues depends on stem cell self-renewal in local niches. Spermatogonial stem cells (SSC) are germline adult stem cells necessary for spermatogenesis and fertility.
D. Bhang +14 more
semanticscholar +1 more source
Stem cell niche: Dynamic neighbor of stem cells
European Journal of Cell Biology, 2019 Stem cell niche is a specialized and dynamic microenvironment around the stem cells which plays a critical role in maintaining the stemness properties of stem cells. Over the years, advancement in the research activity has revealed the various important aspects of stem cell niche including cell-cell interaction, cell-extracellular matrix interaction, a
Anshuman, Singh +4 more
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Advanced Engineering Materials, EarlyView.Herein, environmental scanning electron microscopy (ESEM) is discussed as a powerful extension of conventional SEM for life sciences. By combining high‐resolution imaging with variable pressure and humidity, ESEM allows the analysis of untreated biological materials, supports in situ monitoring of hydration‐driven changes, and advances the functional ...
Jendrian Riedel +6 more
wiley +1 more source