Results 121 to 130 of about 1,144,390 (358)

Stem Cell Research in the Greater Middle East

, 2010
A poster presentation by the International Stem Cell Policy Program on stem cell research in the Middle ...
Matthews, Kirstin R.W., Flynn, Jesse M.
core  

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation [PDF]

, 2016
The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling ...
Wakeham, A., Mana, Miyeko D, Sato, T., Pollett, Aaron, Dominguez-Brauer, Carmen, Tworzyanski, Leanne, Pollett, A., Sabatini, David M., Yilmaz, Omer H., Sheng, Yi, Elia, A. J., Reardon, Colin, Inoue, Satoshi, Cox, Maureen A., Yilmaz, Omer H, Cairns, Robert, Wakeham, Andrew, Haight, J., Fortin, Jérôme M, van Es, Johan H, Cairns, R., Reardon, C., van Es, J. H., Mak, Tak W, Nechanitzky, Robert, Sabatini, D. M., Elia, Andrew J., Brauer, Patrick M, Elia, Andrew J, Hao, Zhenyue, Nechanitzky, R., Clevers, Hans, Brauer, Patrick M., Inoue, S., Yilmaz, O. H., Marques, Ana, Fortin, Jérôme M., Dominguez-Brauer, C., Brauer, P. M., Silvester, Jennifer, Mak, T. W., van Es, Johan H., Fortin, J. M., Sabatini, David M, Mak, Tak W., Cox, Maureen A, Marques, A., Sato, Toshiro, Mana, M. D., Cox, M. A., Sheng, Y., Silvester, J., Tworzyanski, L., Haight, Jillian, Clevers, H., Chio, II, Mana, Miyeko D., Hao, Z., Chio, Iok In Christine   +58 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Immunoregulation of Quercetin and Kynurenic Acid on Human Umbilical Cord Mesenchymal Stem Cells Through Gene Expression of Aryl Hydrocarbon Receptor and Interleukin-6 in Hyperglycemic Milieu

Stem Cells International
Mesenchymal stem cells (MSCs) exhibit great promise for treatment applications because of their immunosuppressive properties. The aryl hydrocarbon receptor (AHR), which is a transcription factor that is activated via ligand, has a pivotal role in ...
Thi Sam Nguyen, Thi Thuy Ngan Nguyen, Thi Phuong Anh Nguyen, Tran Bao Chau Ha, Manh Cuong Nguyen, Syed Shadab Raza, Vinh Truong Do, Hoang Ha Chu   +7 more
doaj   +1 more source

Temporal Gene Expression and DNA Methylation during Embryonic Stem Cell Derivation

Cell Journal, 2018
Objective Dual inhibition of mitogen-activated protein kinase (MAPK) kinase (also known as MEK) and transforming growth factor β (TGFβ) type I receptors by PD0325901 and SB431542, known as R2i has been introduced as a highly efficient approach to the ...
Azam Samadian, Mahdi Hesaraki, Sepideh Mollamohamadi, Behrouz Asgari, Mehdi Totonchi, Hossein Baharvand   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Multilineage Potential Research of Bovine Amniotic Fluid Mesenchymal Stem Cells [PDF]

, 2014
Yuhua Gao, Zhiqiang Zhu, Yuhua Zhao, Jinlian Hua, Yuehui Ma, Weijun Guan   +5 more
openalex   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Intrinsic Innate Immunity of Hepatocytes Suppresses HBV Replication and Is Antagonized by HBx

Viruses
(1) Background: Hepatitis B virus (HBV) belongs to the Hepadnaviridae family of viruses that interact with hepatocytes. HBV infection is a major global health problem.
Chui Zeng, Fayed Attia Koutb Megahed, Yiqiong Guo, Dongmei Sun, Yaru Wang, Qin Liu, Yanwei Bi, Jinghang Li, Qi Zhou, Qingdong Xie, Pingnan Sun, Xiaoling Zhou   +11 more
doaj   +1 more source

Making regulations and drawing up legislation in Islamic countries under conditions of uncertainty, with special reference to embryonic stem cell research [PDF]

, 2005
Sercan Aksoy
openalex   +1 more source