Results 61 to 70 of about 1,144,390 (358)

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

In vitro modulation of Schwann cell behavior by VEGF and PDGF in an inflammatory environment

Scientific Reports, 2022
Peripheral glial cell transplantation with Schwann cells (SCs) is a promising approach for treating spinal cord injury (SCI). However, improvements are needed and one avenue to enhance regenerative functional outcomes is to combine growth factors with ...
Souptik Basu, Indra N. Choudhury, Lynn Nazareth, Anu Chacko, Todd Shelper, Marie-Laure Vial, Jenny A. K. Ekberg, James A. St John   +7 more
doaj   +1 more source

The first reported generation of footprint-free human induced pluripotent stem cell line (SCIKFi001-A) in Indonesia from cGMP grade umbilical cord-derived mesenchymal stem cells (UC-MSCs) using synthetic self-replicating RNA

Stem Cell Research, 2022
Induced pluripotent stem cell (iPSC) line SCIKFi001-A was reprogrammed from cGMP grade umbilical cord derived mesenchymal stem cells (UC-MSCs) via non-integrating, virus free, self-replicating RNA for eventual use in regenerative medicine.
Ricky Sanjaya, Siska Yuliana Sari, Andrian Ibnu Faisal, Matheus Alvin Prawira, Naufalia Faza, Halida P. Widyastuti, Harry Murti   +6 more
doaj   +1 more source

Identifiability and privacy in pluripotent stem cell research

, 2014
Data sharing is an essential element of research; however, recent scientific and social developments have challenged conventional methods for protecting privacy.
Williams, C, Bredenoord, AL, Rooke, Heather, Isasi, R;Andrews, PW;Baltz, JM;Bredenoord, AL;Burton, P;Chiu, IM;Hull, SC;Jung, JW;Kurtz, A;Lomax, G;Ludwig, T;McDonald, M;Morris, C;Ng, HH;Rooke, H;Sharma, A;Stacey, GN;Williams, C;Zeng, F;Knoppers, BM, Andrews, Peter W., Baltz, Jay M, Sharma, A, Zeng, F, Ludwig, Tenneille, Kurtz, A, Morris, Clive, Baltz, Jay M., Knoppers, Bartha Maria, Ng, HH, Isasi, Rosario, McDonald, M, Kurtz, Andreas, Burton, P, Zeng, Fanyi, Chiu, Ing-Ming, Andrews, Peter W, Morris, C, Jung, J-W, Lomax, Geoffrey, Ng, Huck Hui, Stacey, Glyn N., Burton, Paul, Lomax, G, Bredenoord, Annelien L., Sharma, Alka, Hull, SC, Chiu, I-M, Bredenoord, Annelien L, Andrews, PW, Stacey, GN, McDonald, Michael, Stacey, Glyn N, Jung, Ji-Won, Hull, Sara Chandros, Ludwig, T, Rooke, H, Knoppers, BM, Williams, Clare, Isasi, R, Baltz, JM   +44 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

FLT3-ITD Compared with DNMT3A R882 Mutation Is a More Powerful Independent Inferior Prognostic Factor in Adult Acute Myeloid Leukemia Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Cohort Study

Turkish Journal of Hematology, 2018
Objective: This study aimed to evaluate DNMT3A exon 23 mutations and their prognostic impacts in the presence of NPM1 and FLT3 mutations in acute myeloid leukemia (AML) patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT ...
Majid Teremmahi Ardestani, Ahmad Kazemi, Bahram Chahardouli, Saeed Mohammadi, Mohsen Nikbakht, Shahrbano Rostami, Mahdi Jalili, Mohammad Vaezi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh   +9 more
doaj   +1 more source

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

, 2011
A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patients.
Merlos-Suárez, Anna, Sancho, Elena, Munoz, P., Clevers, Hans, Barriga de Vicente, Francisco Martín, 1983-, Rossell, D., Mangues, Ramón, Marta Sevillano, David Rossell, Xavier Hernando-Momblona, Muñoz, Purificación, Batlle Gómez, Eduard, Sevillano, M., Victoria da Silva-Diz, Hans Clevers, María Virtudes Céspedes, Rossell, David, Sevillano, Marta, Merlos-Suarez, A., Céspedes, María Virtudes, da Silva-Diz, V., Silva-Diz, Victoria da, Sancho, E., Iglesias, M., Clevers, H., Mar Iglesias, Eduard Batlle, Barriga, F.M., Jung, Peter, Purificación Muñoz, Peter Jung, Hernando-Momblona, Xavier, da Silva-Diz, Victoria, Iglesias, Mar, Hernando-Momblona, X., Francisco M. Barriga, Iglesias Coma, Mar, Jung, P., Cespedes, M.V., Anna Merlos-Suárez, Batlle, E., Barriga, Francisco M., Batlle, Eduard, Elena Sancho, Mangues, R., Ramón Mangues   +45 more
core   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Paralichthys olivaceus egg extract improves porcine oocyte quality by decreasing oxidative stress

Journal of Animal Science and Technology
This study aimed to assess the influence of Paralichthys olivaceus egg extract (POEE) treatment on the maturation and development of porcine oocytes subjected to oxidative stress during in vitro maturation (IVM).
Seung-Eun Lee, Hyo-Jin Park, Dong-Hun Han, Eun-Seo Lim, Han-Bi Lee, Jae-Wook Yoon, Chan-Oh Park, So-Hee Kim, Seung-Hwan Oh, Do-Geon Lee, Da-Bin Pyeon, Eun-Young Kim, Se-Pill Park   +12 more
doaj   +1 more source