Results 31 to 40 of about 7,886,175 (305)

Neural crest-derived stem cells [PDF]

, 2010
The neural crest is a transient embryonic structure in vertebrates that gives rise to most of the peripheral nervous system (PNS) and to several non-neural cell types, including smooth muscle cells of the cardiovascular system, pigment cells in the skin,
Sommer, L, Shakhova, O
core   +1 more source

Gene and Stem Cell Therapies [PDF]

JAMA, 2001
Gene and stem cell therapies hold promise for the treatment of a wide variety of inherited and acquired human diseases. Identification of genes involved in human disease and development of novel vectors and devices for delivering therapeutic genes to different tissues in vivo have resulted in significant progress in the area of gene therapy.
E H, Kaji, J M, Leiden
openaire   +2 more sources

Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]

, 2006
A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G, Austin G Smith, Heavey Barry, Alexandra Benchoua, Benchoua, Alexandra, Smith, Austin,, Benchoua Alexandra, Sally Lowell, Smith Austin G, Lowell, Sally; id_orcid, Smith, Austin, G., Lowell Sally, Lowell, Sally, Heavey, Barry, Barry Heavey   +14 more
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The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

Cancer Cell International, 2023
Background Chimeric antigen receptor (CAR) T-cells have revolutionized the treatment of CD19- and B-cell maturation antigen-positive haematological malignancies.
Gerard J. Chu, Charles G. Bailey, Rajini Nagarajah, Sharon M. Sagnella, Stephen Adelstein, John E. J. Rasko   +5 more
doaj   +1 more source

Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells

Haematologica, 2022
Even though hematopoietic stem cells (HSC) are characterized by their ability to self-renew and differentiate, they primarily reside in quiescence.
Sarah Warsi, Maria Dahl, Emma M. K. Smith, Anna Rydstrom, Els Mansell, Valgardur Sigurdsson, Julia Sjoberg, Shamit Soneji, Emma Rorby, Kavitha Siva, Tan H. M. Grahn, Yang Liu, Ulrika Blank, Goran Karlsson, Stefan Karlsson   +14 more
doaj   +1 more source

Identifying microRNA determinants of human myelopoiesis

Scientific Reports, 2018
Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes and ...
Megha Rajasekhar, Ulf Schmitz, Stephane Flamant, Justin J.-L. Wong, Charles G. Bailey, William Ritchie, Jeff Holst, John E. J. Rasko   +7 more
doaj   +1 more source

The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo

Journal of Hematology & Oncology, 2017
Background ELF2 (E74-like factor 2) also known as NERF (new Ets-related factor), a member of the Ets family of transcription factors, regulates genes important in B and T cell development, cell cycle progression, and angiogenesis. Conserved ELF2 isoforms,
Fiona H. X. Guan, Charles G. Bailey, Cynthia Metierre, Patrick O’Young, Dadi Gao, Teh Liane Khoo, Jeff Holst, John E. J. Rasko   +7 more
doaj   +1 more source

Combinatorial gene targeting in primary human hematopoietic stem and progenitor cells

Scientific Reports, 2022
The CRISPR/Cas9 system offers enormous versatility for functional genomics but many applications have proven to be challenging in primary human cells compared to cell lines or mouse cells.
Alexandra Bäckström, David Yudovich, Kristijonas Žemaitis, Ludvig Nilsén Falck, Agatheeswaran Subramaniam, Jonas Larsson   +5 more
doaj   +1 more source

Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection [PDF]

, 2009
Background: There is currently no effective AIDS vaccine, emphasizing the importance of developing alternative therapies. Recently, a patient was successfully transplanted with allogeneic, naturally resistant CCR5-negative (CCR5 delta 32) cells, setting ...
Trobridge, Grant D., Chiu Sum Ying, Brian C Beard, Robert A Wu, John J Rossi, Muñoz Nina M., Nina M Muñoz, John J. Rossi, Brian C. Beard, Dorothee von Laer, Laer, Dorothee von, Grant D Trobridge, Beard Brian C., Chiu, Sum Ying, Nina M. Muñoz, Kiem, Hans-Peter, Sum Ying Chiu, Trobridge Grant D., Wu, Robert A., Hans-Peter Kiem, Kiem Hans-Peter, Beard, Brian C., Wu Robert A., von Laer Dorothee, Rossi, John J., Rossi John J., Grant D. Trobridge, Robert A. Wu, Muñoz, Nina M.   +28 more
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The neural stem cell microenvironment [PDF]

, 2008
In mammals, neural stem cells appear early in development and remain active within the central nervous system for the whole life duration of the organism.
Kazanis, I., ffrench-Constant, C., Moss, L., Lathia, J.   +3 more
core   +1 more source